{"id":"W4306153755","doi":"10.1101/2022.10.11.511847","title":"Lysosomal swelling and lysis mediate delivery of C3 toxins to their cytoplasmic targets","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; St. Michael's Hospital; University of Guelph","funders":"","keywords":"Cytoplasm; Cell biology; Cytosol; Pinocytosis; GTPase; Cholera toxin; Cytolysis; Biology; Actin; Endosome; Endocytic cycle; Cytoskeleton; Toxin; Lysosome; Endocytosis; Organelle; Biochemistry; Cell; Intracellular; Microbiology; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001970168,0.0002454673,0.0002129797,0.0001323357,0.0002165988,0.0003786527,0.0001687089,0.0004587257,0.0009599357],"category_scores_gemma":[0.0001780362,0.000107488,0.0003472664,0.0001240366,0.0002914076,0.0002822194,0.0003418325,0.0004743311,0.0003248385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000780008,"about_ca_system_score_gemma":0.0003776496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001594664,"about_ca_topic_score_gemma":0.001030548,"domain_scores_codex":[0.9998136,0.00002916001,0.000008954867,0.00002406634,0.00005185816,0.00007239693],"domain_scores_gemma":[0.9998583,0.00003720765,0.0000352158,0.0000204578,0.00002301154,0.00002583889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008940048,0.000007379353,0.0001276424,0.00002179751,0.000002607732,0.00006260897,0.00001599248,0.00004597735,0.9990271,0.0001310214,0.00002493762,0.0004435695],"study_design_scores_gemma":[0.000007349916,0.00009709707,0.002636385,0.000004799112,0.000003357718,0.0002365916,0.00002717368,0.0008772403,0.9953856,0.00005205029,0.0006692335,0.00000314491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916692,0.001163577,0.005027221,0.0001011955,0.00001671016,0.00004034788,0.0003005934,0.00008478764,0.00159649],"genre_scores_gemma":[0.9969468,0.0002328867,0.001135725,0.00005488854,0.000004446975,0.00002486993,0.000191179,0.00001436721,0.001394924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001594664,"threshold_uncertainty_score":0.005659342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009219969836100975,"score_gpt":0.2066537686242196,"score_spread":0.1974337987881186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}