{"id":"W4306168738","doi":"10.1097/txd.0000000000001394","title":"The Role of Dynamic DNA Methylation in Liver Transplant Rejection in Children","year":2022,"lang":"en","type":"article","venue":"Transplantation Direct","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Differentially methylated regions; DNA methylation; Epigenetics; Methylation; Major histocompatibility complex; Promoter; Biology; MHC class I; Single-nucleotide polymorphism; Gene; Molecular biology; Genetics; Medicine; Immunology; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004713924,0.0001157767,0.0002126063,0.0003127552,0.0001076066,0.000006777116,0.00008706797,0.00004800889,0.00009797155],"category_scores_gemma":[0.000005473017,0.00009855605,0.00008054945,0.000489959,0.00003336235,0.0000837007,0.000003552427,0.0002340284,0.000002329953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001155269,"about_ca_system_score_gemma":0.0000503998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005325978,"about_ca_topic_score_gemma":0.0007271637,"domain_scores_codex":[0.9987376,0.000179506,0.0004237968,0.000196817,0.0002940398,0.0001682378],"domain_scores_gemma":[0.9995771,0.000145573,0.00009299751,0.000134855,0.00002087943,0.00002859725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002395137,0.0003687098,0.9048254,0.0003006514,0.00008314398,0.00006863404,0.009675261,0.0006038959,0.04564129,0.0009233368,0.000008043623,0.03510651],"study_design_scores_gemma":[0.001602806,0.0001643214,0.9370832,0.00006115962,0.0001033941,0.0001430066,0.000281385,0.001421151,0.05870407,0.0002269043,0.00009267589,0.0001158754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964456,0.0007032321,0.0002717189,0.0001652832,0.00005498476,0.0006675865,0.0001138344,0.00007317781,0.001504581],"genre_scores_gemma":[0.993166,0.00610983,0.0001718716,0.0000452981,0.000008146396,0.00008773542,0.0003054994,0.00001823921,0.00008734505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03499063,"threshold_uncertainty_score":0.4018999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005496960820906956,"score_gpt":0.2429951809621862,"score_spread":0.2374982201412792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}