{"id":"W4306173791","doi":"10.1016/j.ymthe.2022.10.004","title":"Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Hepatocellular carcinoma; Clotting factor; Ectopic expression; Cancer research; Hepatocyte; Carcinoma; Internal medicine; Medicine; Biology; Biochemistry; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001564487,0.0002080433,0.000280795,0.0005515176,0.0002527013,0.000216749,0.0002213239,0.0003523369,0.001537222],"category_scores_gemma":[0.0003072822,0.0001378982,0.0001971232,0.0002488123,0.0004022052,0.0001514739,0.0002207147,0.0004627838,0.0002967411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002837007,"about_ca_system_score_gemma":0.0001533979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005064573,"about_ca_topic_score_gemma":0.0003367497,"domain_scores_codex":[0.9998604,0.00003050364,0.00001624231,0.00002065263,0.00004546456,0.00002675327],"domain_scores_gemma":[0.9998006,0.00005316386,0.00003943458,0.00003150473,0.00002110258,0.00005412506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006908323,0.00006487046,0.002427677,0.00004254759,0.00001652112,0.005701825,0.00004380038,0.0001248403,0.9873584,0.000546785,0.0001603512,0.002821623],"study_design_scores_gemma":[0.00004982587,0.0003741313,0.01721888,0.000003774019,0.00005179574,0.01735961,0.0001364933,0.001568981,0.9607663,0.0003757815,0.002082464,0.00001202253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940441,0.0007764488,0.003180575,0.0002525207,0.00006808827,0.00002016282,0.00009934828,0.0001407835,0.001417888],"genre_scores_gemma":[0.9985782,0.0001868037,0.0003565502,0.00002036162,0.00001247206,0.000005883224,0.00004814838,0.00001661826,0.000774944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537222,"threshold_uncertainty_score":0.00514257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577628459068244,"score_gpt":0.2566403392164723,"score_spread":0.2408640546257899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}