{"id":"W4306173791","doi":"10.1016/j.ymthe.2022.10.004","title":"Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Hepatocellular carcinoma; Clotting factor; Ectopic expression; Cancer research; Hepatocyte; Carcinoma; Internal medicine; Medicine; Biology; Biochemistry; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378217,0.0001703195,0.000151392,0.00008313765,0.0001666932,0.0000242436,0.0001233333,0.0001001319,0.00003589005],"category_scores_gemma":[0.00002376896,0.0001869707,0.00008938553,0.000101916,0.00002390047,0.000004640333,0.0001070007,0.0001037794,6.979499e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006369476,"about_ca_system_score_gemma":0.00006608714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008778161,"about_ca_topic_score_gemma":0.000008823856,"domain_scores_codex":[0.9988595,0.000111929,0.000198398,0.0004283969,0.0001512171,0.000250555],"domain_scores_gemma":[0.9995445,0.00001472981,0.00008535603,0.0002696403,0.00003063731,0.00005512884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002223513,0.00003439337,0.02871045,0.00001185526,0.00002960912,0.00001425067,0.0002153863,0.0004103787,0.9663849,0.00002519487,0.00003180389,0.003909366],"study_design_scores_gemma":[0.001989083,0.0004172296,0.002707643,0.00001213899,0.000007322111,0.00002672958,0.00008088362,0.002420825,0.9796712,0.0001672692,0.01225927,0.0002404259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888617,0.008749641,0.001428125,0.0001166329,0.0001119572,0.0006767277,0.00001705904,0.00001591122,0.00002220561],"genre_scores_gemma":[0.9985769,0.000223037,0.0003729138,0.000206482,0.00007260698,0.0002921857,0.0001053505,0.00004801341,0.0001024852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0260028,"threshold_uncertainty_score":0.7624444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577628459068244,"score_gpt":0.2566403392164723,"score_spread":0.2408640546257899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}