{"id":"W4306173821","doi":"10.1016/j.jcyt.2022.09.006","title":"CD73 activity of mesenchymal stromal cell-derived extracellular vesicle preparations is detergent-resistant and does not correlate with immunomodulatory capabilities","year":2022,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Universität Duisburg-Essen; European Commission; Stem Cell Network","keywords":"Mesenchymal stem cell; Extracellular vesicles; Stromal cell; Extracellular; Extracellular vesicle; Microvesicles; Cell biology; Chemistry; Cell; Vesicle; Cancer research; Biology; Biochemistry; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003184729,0.0003870484,0.0002440445,0.0004581487,0.0001751639,0.0004839828,0.0001565971,0.0002948034,0.000761113],"category_scores_gemma":[0.000500067,0.00009935489,0.0003100433,0.0002925012,0.0002309573,0.0002929307,0.0002423897,0.0004219368,0.0003131014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000251051,"about_ca_system_score_gemma":0.0001769596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002975301,"about_ca_topic_score_gemma":0.0003293972,"domain_scores_codex":[0.9995011,0.00008040979,0.00007257328,0.00009270675,0.0001766274,0.00007663761],"domain_scores_gemma":[0.9996413,0.00009531367,0.00009558758,0.0000483983,0.00008723092,0.00003219775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000963042,0.00002042922,0.0009092833,0.00005621844,0.00001563144,0.00004294808,0.00001575791,0.00003554967,0.995312,0.00008927118,0.00001532249,0.003391235],"study_design_scores_gemma":[0.000004180233,0.0001056809,0.003498577,0.000007716518,0.00002289671,0.0002862197,0.000020213,0.0002241751,0.9947902,0.00003620981,0.001000615,0.000003384536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760295,0.005993382,0.01429741,0.0001018536,0.00004862416,0.00007867066,0.0004862611,0.00007852374,0.002885899],"genre_scores_gemma":[0.9925218,0.001236157,0.004150804,0.00003585308,0.00001441057,0.00005103648,0.0008849721,0.00001726337,0.001087654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000761113,"threshold_uncertainty_score":0.002546191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006557335920539433,"score_gpt":0.2127126147966709,"score_spread":0.2061552788761315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}