{"id":"W4306179806","doi":"10.1038/s41467-022-33597-y","title":"Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Johns Hopkins Bloomberg School of Public Health; Department of Pathology, Johns Hopkins University; Newfoundland and Labrador; National Institute of Biomedical Imaging and Bioengineering; Sidney Kimmel Comprehensive Cancer Center; Emerson Collective; Maryland Stem Cell Research Fund; Johns Hopkins University; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation; U.S. Department of Defense","keywords":"Cytotoxic T cell; Biology; Cell biology; Antigen-presenting cell; CD8; Major histocompatibility complex; T cell; Streptamer; Immunotherapy; Antigen; Immunology; Effector; MHC class II; Cancer research; Immune system; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000372344,0.0001011042,0.000188469,0.0001689088,0.0004185924,0.00001277172,0.0002949249,0.00008950035,0.001015642],"category_scores_gemma":[0.00005482489,0.00009770109,0.00008484955,0.0005215664,0.0001894297,0.00005681283,0.0001671321,0.0008455766,0.000007161781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001222617,"about_ca_system_score_gemma":0.0001301934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004861877,"about_ca_topic_score_gemma":0.00003647058,"domain_scores_codex":[0.9988293,0.000324885,0.0002039556,0.0001674794,0.0003286907,0.0001456682],"domain_scores_gemma":[0.997965,0.0005001962,0.00009395908,0.00118352,0.0001984348,0.00005884096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003660373,0.000487357,0.007874551,0.00002445238,0.0000541448,4.924845e-7,0.0004538945,0.0001259908,0.985931,0.0002002091,0.0004883227,0.003993492],"study_design_scores_gemma":[0.007864672,0.002416061,0.2441095,0.00008246103,0.0001940559,0.00002941214,0.001746718,0.0218415,0.4869982,0.0001417316,0.2341173,0.0004584076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839365,0.009535127,0.000122793,0.003140609,0.0001084885,0.0007526596,0.00007158025,0.00005451415,0.002277758],"genre_scores_gemma":[0.9957093,0.0003454288,0.001598989,0.0003233556,0.00002502764,0.0002576298,0.0001612454,0.0000234548,0.001555576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4989328,"threshold_uncertainty_score":0.9998975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181179341991284,"score_gpt":0.3199720329386759,"score_spread":0.2981602395187631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}