{"id":"W4306179806","doi":"10.1038/s41467-022-33597-y","title":"Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Johns Hopkins Bloomberg School of Public Health; Department of Pathology, Johns Hopkins University; Newfoundland and Labrador; National Institute of Biomedical Imaging and Bioengineering; Sidney Kimmel Comprehensive Cancer Center; Emerson Collective; Maryland Stem Cell Research Fund; Johns Hopkins University; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation; U.S. Department of Defense","keywords":"Cytotoxic T cell; Biology; Cell biology; Antigen-presenting cell; CD8; Major histocompatibility complex; T cell; Streptamer; Immunotherapy; Antigen; Immunology; Effector; MHC class II; Cancer research; Immune system; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050702,0.0003168544,0.0001451843,0.0001787119,0.00008802641,0.0002834128,0.0001395438,0.0003047603,0.0009786615],"category_scores_gemma":[0.0001031315,0.0001034308,0.0001410791,0.00007248692,0.0001521588,0.00019493,0.0001699019,0.0003352702,0.0002396697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001995335,"about_ca_system_score_gemma":0.0001421346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002316292,"about_ca_topic_score_gemma":0.0003542741,"domain_scores_codex":[0.9998984,0.00001971776,0.000007464872,0.00001906782,0.00002670208,0.00002861035],"domain_scores_gemma":[0.9999527,0.00001319563,0.000009355655,0.000005676305,0.000007647298,0.00001158333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006370823,0.00004410942,0.00004337486,0.00002792875,0.00000237359,0.0000180852,0.000006850836,0.0001682622,0.9972041,0.0001357495,0.00005589178,0.002229625],"study_design_scores_gemma":[0.00001186685,0.0002628962,0.000201988,0.00000207742,0.000007664887,0.00003086844,0.000004679477,0.001293052,0.9967393,0.00003425615,0.00140967,0.000001600265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846066,0.001158683,0.009536296,0.000107792,0.0000821564,0.000053935,0.00007499304,0.0002311634,0.004148364],"genre_scores_gemma":[0.9935319,0.0003372228,0.003821582,0.00003948244,0.00001665967,0.00002784594,0.00004693174,0.00001811419,0.002160024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009786615,"threshold_uncertainty_score":0.003273904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181179341991284,"score_gpt":0.3199720329386759,"score_spread":0.2981602395187631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}