{"id":"W4306247180","doi":"10.1101/2022.10.14.512102","title":"Muscle stem cell function is impaired in absence of Talpid3 - a gene required for primary cilia formation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Medical Research Council; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; British Heart Foundation; UK Research and Innovation","keywords":"Cell biology; Biology; Wnt signaling pathway; Smoothened; Myocyte; Regeneration (biology); Cilium; Stem cell; Skeletal muscle; Hedgehog signaling pathway; Myogenesis; Anatomy; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137754,0.0005913879,0.00037776,0.0006741051,0.0002654671,0.0003526793,0.000349547,0.0006977631,0.00357469],"category_scores_gemma":[0.0001216822,0.0002541952,0.0004372221,0.0002361248,0.0007097154,0.0002012228,0.0003659629,0.0008077337,0.0008604824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003691706,"about_ca_system_score_gemma":0.0003018093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092231,"about_ca_topic_score_gemma":0.001507586,"domain_scores_codex":[0.9997668,0.00001814299,0.00003531421,0.00005277773,0.00007608587,0.0000509877],"domain_scores_gemma":[0.9996325,0.00003238381,0.0001398438,0.00002045179,0.00001791487,0.0001568766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005486501,0.00001246496,0.0001148367,0.00002231252,0.000004463807,0.0001084288,0.000007183729,0.00002511939,0.9993203,0.00006707333,0.00003341498,0.0002295929],"study_design_scores_gemma":[0.00003629106,0.0002158221,0.01340213,0.00001609212,0.00003807448,0.001313989,0.00006795282,0.001323914,0.9809473,0.0001051054,0.00252365,0.00000965429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927685,0.0006465679,0.003054504,0.0001666479,0.00006195793,0.0000305319,0.001621963,0.0003522503,0.001296969],"genre_scores_gemma":[0.9914339,0.0003654793,0.001357767,0.00008104372,0.00001019368,0.00004517965,0.00130231,0.00008265218,0.0053215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00357469,"threshold_uncertainty_score":0.01195854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133573865016679,"score_gpt":0.2073697353539577,"score_spread":0.1960339967037909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}