{"id":"W4306249203","doi":"10.1101/2022.10.11.509802","title":"A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementia","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Genome-wide association study; Dementia; Vascular dementia; Genetic association; Disease; Genetic architecture; Biology; Genetics; Diabetes mellitus; Bioinformatics; Medicine; Single-nucleotide polymorphism; Gene; Quantitative trait locus; Internal medicine; Genotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008554335,0.002222669,0.00521269,0.004687897,0.001136887,0.003336842,0.001784874,0.001560327,0.003467367],"category_scores_gemma":[0.01461894,0.001187469,0.02590688,0.007394318,0.0004923738,0.0009715377,0.001724144,0.002137753,0.0003423029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007592501,"about_ca_system_score_gemma":0.0009867479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008313396,"about_ca_topic_score_gemma":0.01063077,"domain_scores_codex":[0.9923339,0.003237197,0.0009996104,0.002264837,0.0006353537,0.0005291671],"domain_scores_gemma":[0.9888639,0.006754124,0.001232731,0.001921939,0.0007598175,0.0004674594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003943057,0.00004537933,0.4054127,0.003830687,0.5682451,0.0008456798,0.00008829498,0.00244048,0.001767789,0.0003359996,0.002113797,0.01093109],"study_design_scores_gemma":[0.0007257165,0.0003593749,0.3039938,0.0008151828,0.6816889,0.001041219,0.0001670981,0.005667304,0.0008187184,0.001593837,0.00305678,0.00007203255],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6196793,0.3440937,0.0173402,0.002105787,0.001152536,0.0001898837,0.01196233,0.0007367507,0.002739462],"genre_scores_gemma":[0.9808904,0.01339701,0.00225893,0.0003509267,0.0001933862,0.0001002177,0.002335741,0.00008862788,0.00038469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008554335,"threshold_uncertainty_score":0.04524022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04615888429301856,"score_gpt":0.2656977162057499,"score_spread":0.2195388319127313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}