{"id":"W4306249794","doi":"10.21203/rs.3.rs-2143931/v1","title":"Lipid Nanoparticle Mediated Delivery of Docetaxel Prodrug for Exploiting Full Potential of Gold Radiosensitizers in the Treatment of Pancreatic Cancer.","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; British Columbia Knowledge Development Fund; National Institutes of Health; University of Victoria","keywords":"Docetaxel; In vivo; Prodrug; Pancreatic cancer; In vitro; Chemistry; Pharmacology; Colloidal gold; Toxicity; Cancer; Drug delivery; Cancer research; Medicine; Internal medicine; Nanoparticle; Biochemistry; Nanotechnology; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003594644,0.0002666122,0.0008237853,0.0003977851,0.0001217239,0.00004246214,0.0007396654,0.0001190701,0.0002107074],"category_scores_gemma":[0.0005609617,0.0002080581,0.0002761324,0.000696866,0.0004280815,0.0001066456,0.0004022509,0.0003041739,0.000004693695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005638821,"about_ca_system_score_gemma":0.001006521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005047443,"about_ca_topic_score_gemma":0.0002964603,"domain_scores_codex":[0.9943185,0.001642936,0.001021532,0.0006233363,0.001633581,0.0007601233],"domain_scores_gemma":[0.9957784,0.001937497,0.0005159468,0.0009182644,0.0007453238,0.000104588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001555959,0.001240213,0.001295833,0.001904544,0.00006888145,0.00003725317,0.005042811,0.01280084,0.9748586,0.00004681413,0.0001529952,0.0009952539],"study_design_scores_gemma":[0.002229324,0.001749971,0.001080085,0.000708448,0.0001018298,0.000003039565,0.007988389,0.006434289,0.9792861,0.0001549075,0.0000582947,0.000205366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924881,0.002305581,0.00001075798,0.0003742301,0.0002432283,0.003183779,0.001343457,0.00002621986,0.0000245981],"genre_scores_gemma":[0.9965333,0.001138991,0.0003866929,0.000009057379,0.0001226609,0.001649795,0.00008017621,0.0000400579,0.00003922601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006366554,"threshold_uncertainty_score":0.8484362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05466502933374587,"score_gpt":0.3440363041821731,"score_spread":0.2893712748484273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}