{"id":"W4306252870","doi":"10.1038/s41380-022-01798-y","title":"Antipsychotics impair regulation of glucose metabolism by central glucose","year":2022,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; The Scarborough Hospital; Diabetes Canada; University of Toronto; Centre for Addiction and Mental Health","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Government of Canada; National Institute of Mental Health; U.S. Department of Health and Human Services","keywords":"Haloperidol; Endocrinology; Internal medicine; Olanzapine; Glucose homeostasis; Clozapine; Carbohydrate metabolism; Antipsychotic; Glucose uptake; Glucose transporter; Blood sugar regulation; Medicine; Pharmacology; Diabetes mellitus; Insulin; Insulin resistance; Schizophrenia (object-oriented programming); Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001643551,0.0001585892,0.0003148086,0.0001263987,0.0001003322,0.000008357534,0.0001007707,0.00005002379,0.0008248609],"category_scores_gemma":[0.0000370435,0.0001603364,0.0002080499,0.0003927261,0.00004833844,0.00003659989,0.00004295961,0.0002028561,0.00001213474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004356661,"about_ca_system_score_gemma":0.0001417946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001365209,"about_ca_topic_score_gemma":3.948937e-7,"domain_scores_codex":[0.9985436,0.000104445,0.0003404507,0.0002653417,0.0004582941,0.0002878473],"domain_scores_gemma":[0.9991813,0.00001551534,0.0001470488,0.0004403843,0.00005387979,0.0001618861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009555286,0.001441157,0.0314061,0.0001467853,0.0003125191,0.00001234621,0.0001607779,0.0001909842,0.9023854,0.008102574,0.05349595,0.001389938],"study_design_scores_gemma":[0.0153994,0.001651092,0.3872514,0.0001188018,0.001407809,0.0002282956,0.001029112,0.003862428,0.4676219,0.01073892,0.1097778,0.0009130226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842378,0.008590005,0.001121246,0.001547533,0.001517994,0.0003129868,0.00005861609,0.00007769958,0.002536082],"genre_scores_gemma":[0.9937503,0.00004787831,0.003428826,0.002009154,0.00009903165,0.00002149035,0.000209961,0.00003467457,0.0003986381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4347634,"threshold_uncertainty_score":0.9031648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004575256173604453,"score_gpt":0.2241949796351726,"score_spread":0.2196197234615681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}