{"id":"W4306254535","doi":"10.1016/j.htct.2022.09.020","title":"LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA","year":2022,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Pyruvate kinase; Thalassemia; Anemia; Gastroenterology; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007256154,0.0002886527,0.0007114839,0.0001470405,0.0003115206,0.0005097818,0.0001789426,0.0004133033,0.001418381],"category_scores_gemma":[0.0009264589,0.0001516378,0.0005595112,0.0002004652,0.0002244337,0.0004608172,0.0002354997,0.001000804,0.0003327318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039756,"about_ca_system_score_gemma":0.0003913086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004220257,"about_ca_topic_score_gemma":0.0007693619,"domain_scores_codex":[0.9997793,0.00007562131,0.00002775529,0.00003748421,0.00002977117,0.00005008967],"domain_scores_gemma":[0.9995498,0.0000808858,0.0001589038,0.0000200449,0.00003561082,0.0001546943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4766984,0.02529317,0.1051604,0.001233908,0.00197351,0.0008058097,0.0005021527,0.00188304,0.02721072,0.0001914734,0.004440775,0.3546067],"study_design_scores_gemma":[0.07985164,0.6069745,0.2967634,0.0002108717,0.001997032,0.001212029,0.000323586,0.001945156,0.004490378,0.0002280312,0.005957888,0.00004545768],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994843,0.003447788,0.0001666455,0.0001548612,0.00003869954,0.0001848914,0.000397955,0.00001782687,0.0007483705],"genre_scores_gemma":[0.9970437,0.001166673,0.0001770673,0.0002531141,0.00008143159,0.0002027879,0.0004665174,0.000002613306,0.0006061859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001418381,"threshold_uncertainty_score":0.004744947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008207481707575523,"score_gpt":0.2342024869547788,"score_spread":0.2259950052472033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}