{"id":"W4306254535","doi":"10.1016/j.htct.2022.09.020","title":"LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA","year":2022,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Pyruvate kinase; Thalassemia; Anemia; Gastroenterology; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002132744,0.0002751079,0.000603402,0.0001246961,0.0003022228,0.000006813697,0.0001325203,0.0001912373,0.0006457961],"category_scores_gemma":[0.000004282098,0.0001547249,0.00009175427,0.000359001,0.0002557676,0.00004610504,0.00004649123,0.0006019909,8.7731e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002902783,"about_ca_system_score_gemma":0.0001264907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00013862,"about_ca_topic_score_gemma":0.0002159122,"domain_scores_codex":[0.9983351,0.0001788811,0.0004181422,0.0004455514,0.0002995984,0.0003226904],"domain_scores_gemma":[0.9993067,0.000115617,0.00009792118,0.0003093255,0.00003497826,0.00013543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07236649,0.004214011,0.6797979,0.001192675,0.0003336219,0.001028878,0.01478493,0.00003891096,0.1825428,0.0001810827,0.0001411444,0.04337749],"study_design_scores_gemma":[0.1177917,0.006706054,0.6456573,0.001541344,0.0003570878,0.002390025,0.007579405,0.0001958394,0.214638,0.00004733873,0.002157537,0.0009383264],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936119,0.002551349,0.00004492974,0.001915785,0.0001247461,0.001366229,0.00001415607,0.00002730465,0.0003435928],"genre_scores_gemma":[0.9777851,0.02131693,0.00003804186,0.0004973037,0.000007612116,0.00005832064,0.00001357226,0.00003601792,0.0002470817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04542524,"threshold_uncertainty_score":0.7071014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008207481707575523,"score_gpt":0.2342024869547788,"score_spread":0.2259950052472033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}