{"id":"W4306255541","doi":"10.1093/eurheartj/ehac544.917","title":"Aptamer proteomics for biomarker discovery in heart failure with reduced ejection fraction","year":2022,"lang":"en","type":"article","venue":"European Heart Journal","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Medicine; Mendelian randomization; Heart failure; Clinical endpoint; Biomarker; Biomarker discovery; Internal medicine; Proteomics; Proportional hazards model; Ejection fraction; Clinical trial; Bioinformatics; Natriuretic peptide; Oncology; Computational biology; Cardiology; Biology; Genotype; Genetics; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004048035,0.0005279452,0.0008038388,0.001011125,0.000181117,0.0006926281,0.0004185951,0.0005713829,0.001070545],"category_scores_gemma":[0.004432597,0.0002232539,0.0005723232,0.0006996315,0.0003808696,0.0003523481,0.0006551816,0.0005162514,0.0001845607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003736887,"about_ca_system_score_gemma":0.0004357726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002735821,"about_ca_topic_score_gemma":0.0003342384,"domain_scores_codex":[0.9982609,0.0008769121,0.00008609436,0.000370715,0.000317203,0.00008812342],"domain_scores_gemma":[0.9975579,0.001094359,0.0008355376,0.0002115472,0.0001865527,0.0001141504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01625986,0.0009372834,0.2011657,0.00133332,0.002778936,0.0008388511,0.0002440495,0.0249864,0.4771422,0.00418266,0.004497381,0.2656334],"study_design_scores_gemma":[0.002224752,0.01352343,0.3213897,0.0002334784,0.003062902,0.005258523,0.000234277,0.2680298,0.3405418,0.02579623,0.01949604,0.0002089665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8939243,0.009965847,0.09043688,0.001260769,0.0002357437,0.0002978148,0.001517946,0.0005830046,0.001777847],"genre_scores_gemma":[0.9602931,0.001048334,0.03671188,0.0004810687,0.0001167474,0.0002062063,0.0004580071,0.00002297733,0.0006616376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004048035,"threshold_uncertainty_score":0.02140832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02479290952926411,"score_gpt":0.2764566038509536,"score_spread":0.2516636943216895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}