{"id":"W4306293668","doi":"10.1007/s12192-022-01302-z","title":"A novel synthetic chalcone derivative, 2,4,6-trimethoxy-4′-nitrochalcone (Ch-19), exerted anti-tumor effects through stimulating ROS accumulation and inducing apoptosis in esophageal cancer cells","year":2022,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Science and Technology Innovation Talents in Universities of Henan Province; National College Students Innovation and Entrepreneurship Training Program; Natural Science Foundation of Henan Province","keywords":"Chalcone; Apoptosis; Esophageal cancer; Cancer research; Chemistry; Cancer; Potency; Cancer cell; Cell culture; Pharmacology; Medicine; Biology; Biochemistry; Internal medicine; Stereochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001766867,0.0003266732,0.0005294384,0.0000673551,0.0004428505,0.00006216094,0.000142907,0.0001242185,0.0003118065],"category_scores_gemma":[0.0000823149,0.0002836517,0.00006089132,0.0002002973,0.0001148238,0.0001620772,0.0003194363,0.0003485858,6.022629e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007673904,"about_ca_system_score_gemma":0.00002425321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001594342,"about_ca_topic_score_gemma":0.00002904336,"domain_scores_codex":[0.9982656,0.0001098199,0.0003283473,0.0006701461,0.0002174001,0.0004086397],"domain_scores_gemma":[0.9986414,0.0008168992,0.0002288208,0.0001851257,0.00002753479,0.0001001843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007412206,0.0004519246,0.01690436,0.0004704551,0.00002979943,0.000008858809,0.0008863436,0.0008549592,0.9718368,0.00002610879,0.000001135139,0.008455151],"study_design_scores_gemma":[0.001723076,0.00008123692,0.02137787,0.0002003643,0.00005175645,0.000005686651,0.0009393217,0.00877636,0.9663384,0.00006825849,0.00003936531,0.000398322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969319,0.002086291,0.0002393129,0.00008039572,0.00007761495,0.0002384877,0.0001279888,0.00005763472,0.0001603524],"genre_scores_gemma":[0.9988614,0.0002403502,0.0004450184,0.00008377261,0.00009360925,0.0001897503,0.00002485909,0.00003077506,0.00003040653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008056829,"threshold_uncertainty_score":0.9999616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054642947878549,"score_gpt":0.2799394570399924,"score_spread":0.2393930275612069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}