{"id":"W4306293668","doi":"10.1007/s12192-022-01302-z","title":"A novel synthetic chalcone derivative, 2,4,6-trimethoxy-4′-nitrochalcone (Ch-19), exerted anti-tumor effects through stimulating ROS accumulation and inducing apoptosis in esophageal cancer cells","year":2022,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Science and Technology Innovation Talents in Universities of Henan Province; National College Students Innovation and Entrepreneurship Training Program; Natural Science Foundation of Henan Province","keywords":"Chalcone; Apoptosis; Esophageal cancer; Cancer research; Chemistry; Cancer; Potency; Cancer cell; Cell culture; Pharmacology; Medicine; Biology; Biochemistry; Internal medicine; Stereochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004259577,0.0002754936,0.0001781746,0.0002244829,0.0001072433,0.00007527405,0.0001465862,0.0001443671,0.001223651],"category_scores_gemma":[0.00004568376,0.00004523771,0.000141742,0.0001619216,0.0001394263,0.000126372,0.00008240682,0.0002309648,0.0002080675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00016021,"about_ca_system_score_gemma":0.0002292889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004882205,"about_ca_topic_score_gemma":0.001392877,"domain_scores_codex":[0.9999804,0.000002840797,0.000001682,0.000005021629,0.000004760426,0.000005277499],"domain_scores_gemma":[0.9999655,0.000003969521,0.000007470772,0.000002863368,0.000008848971,0.00001125048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001780824,0.00005628646,0.0002149158,0.000135627,0.000007295594,0.0001341719,0.00001134233,0.0002905501,0.9919195,0.0001659754,0.0001038877,0.006782295],"study_design_scores_gemma":[0.00006283919,0.00220655,0.003447605,0.000009816952,0.00003009364,0.0003512695,0.00001992413,0.0007257846,0.9867872,0.00007002467,0.006278367,0.00001053002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823298,0.006577857,0.005566266,0.0001752568,0.00007694131,0.0001393905,0.0006770812,0.0001517501,0.004305699],"genre_scores_gemma":[0.990236,0.003432325,0.003174966,0.0000964826,0.00002248656,0.00003442635,0.0005583357,0.00001174369,0.002433248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223651,"threshold_uncertainty_score":0.004093528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054642947878549,"score_gpt":0.2799394570399924,"score_spread":0.2393930275612069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}