{"id":"W4306391018","doi":"10.1002/acn3.51672","title":"<scp>CSF</scp> glial markers are elevated in a subset of patients with genetic frontotemporal dementia","year":2022,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Université Laval; Health Sciences Centre; Occupational Cancer Research Centre; Montreal Neurological Institute and Hospital; University of Toronto; Western University; Sunnybrook Health Science Centre","funders":"H2020 Marie Skłodowska-Curie Actions; NIHR Cambridge Biomedical Research Centre; European Research Council; Canadian Institutes of Health Research; Tau Consortium; Olav Thon Stiftelsen; Alzheimer Nederland; Stichting Dioraphte; Universiteit Hasselt; Universität Ulm; Medical Research Council; Medical Research Council Canada; Deutsches Zentrum für Neurodegenerative Erkrankungen; Vetenskapsrådet; Stockholms Läns Landsting; KU Leuven; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Centre National de la Recherche Scientifique; Wolfson Foundation; Familjen Erling-Perssons Stiftelse; European Commission; University of Cambridge; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Universidad Internacional de La Rioja; National Brain Appeal; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Wellcome Trust; Ministero della Salute; Alzheimer's Society; Deutsche Forschungsgemeinschaft; Weston Brain Institute; ZonMw; Alzheimer's Drug Discovery Foundation; Brain Research UK; Universidad de La Rioja; Institut National de la Santé et de la Recherche Médicale; EU Joint Programme – Neurodegenerative Disease Research; Universiteit Antwerpen; Stiftelsen för Gamla Tjänarinnor; Alzheimer's Association; UK Dementia Research Institute; Ontario Brain Institute","keywords":"Frontotemporal dementia; TREM2; Medicine; Cerebrospinal fluid; C9orf72; Internal medicine; Oncology; Mutation; Neuroinflammation; Dementia; Confidence interval; Gastroenterology; Pathology; Disease; Microglia; Inflammation; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002534271,0.000738664,0.0004936514,0.001203485,0.0006177285,0.0006703023,0.0003032736,0.0005621444,0.001596849],"category_scores_gemma":[0.001484794,0.0002191554,0.0002936904,0.0007365244,0.0003051237,0.000298243,0.000283221,0.0003413669,0.0002656932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002869701,"about_ca_system_score_gemma":0.000208816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003906052,"about_ca_topic_score_gemma":0.003294623,"domain_scores_codex":[0.9998087,0.0000265854,0.00003034137,0.00004966807,0.000050034,0.00003459935],"domain_scores_gemma":[0.9993629,0.0001039286,0.0002953811,0.00003393138,0.0001075584,0.00009633314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005427164,0.00003756808,0.9913139,0.00002492251,0.00008129631,0.001822768,0.0001677634,0.0000558516,0.003161972,0.00002102412,0.0002240617,0.002546183],"study_design_scores_gemma":[0.000008794017,0.000102549,0.9962596,0.000007163803,0.00004124054,0.002864874,0.0001395944,0.0001225724,0.0002815794,0.00004448686,0.0001233962,0.000004302275],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993711,0.0001594072,0.0000296787,0.00002326444,0.000005486532,0.000002585438,0.0001405772,0.000005966785,0.0002620279],"genre_scores_gemma":[0.9996042,0.00005543592,0.00006067809,0.00001883395,0.000009990621,0.000004010675,0.0001624803,0.000001754582,0.00008260669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003906052,"threshold_uncertainty_score":0.007766604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07428405142406914,"score_gpt":0.315770348311503,"score_spread":0.2414862968874338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}