{"id":"W4306392827","doi":"10.1002/jbt.23243","title":"Mercury and methylmercury differentially modulate hepatic cytochrome P450 1A1 and 1A2 in vivo and in vitro","year":2022,"lang":"en","type":"article","venue":"Journal of Biochemical and Molecular Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aryl hydrocarbon receptor; Chemistry; Cytochrome P450; In vivo; In vitro; CYP1B1; Methylmercury; Biochemistry; Enzyme; Gene; Environmental chemistry; Transcription factor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327985,0.0003729762,0.0003012237,0.0003158727,0.0001391342,0.0002080288,0.0001384976,0.0002575505,0.001623805],"category_scores_gemma":[0.0001160878,0.0002114468,0.0002985846,0.0002562164,0.0001936935,0.000133505,0.0001412766,0.0004097906,0.0003420607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002518691,"about_ca_system_score_gemma":0.0001849053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001278387,"about_ca_topic_score_gemma":0.002634914,"domain_scores_codex":[0.9998226,0.00004759632,0.00001130184,0.00003025943,0.00004418815,0.00004401612],"domain_scores_gemma":[0.9998865,0.00002779567,0.00002399496,0.00001397606,0.00001956645,0.00002818007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005114354,0.0000656335,0.0003754548,0.00002898681,0.00001096184,0.00002481417,0.00001102888,0.00004653366,0.9982351,0.00002135576,0.00004036612,0.000628304],"study_design_scores_gemma":[0.0000320248,0.001558187,0.009762897,0.00000373799,0.00003780295,0.00008178513,0.00003362116,0.0003758014,0.9868701,0.00002391767,0.001215232,0.000005009966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959983,0.001794257,0.0008892324,0.00009107685,0.0000436284,0.00001920649,0.0003411585,0.00005275137,0.0007704353],"genre_scores_gemma":[0.9922247,0.001246534,0.0009743982,0.00008012933,0.00002802405,0.00003886849,0.0007226319,0.00001578722,0.00466898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623805,"threshold_uncertainty_score":0.005432189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700171959952816,"score_gpt":0.347044667466597,"score_spread":0.3200429478670688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}