{"id":"W4306392827","doi":"10.1002/jbt.23243","title":"Mercury and methylmercury differentially modulate hepatic cytochrome P450 1A1 and 1A2 in vivo and in vitro","year":2022,"lang":"en","type":"article","venue":"Journal of Biochemical and Molecular Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aryl hydrocarbon receptor; Chemistry; Cytochrome P450; In vivo; In vitro; CYP1B1; Methylmercury; Biochemistry; Enzyme; Gene; Environmental chemistry; Transcription factor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008135497,0.0002328959,0.0005868244,0.0003335223,0.0001021891,0.00001806835,0.000147403,0.0002356921,0.0001205858],"category_scores_gemma":[0.00007562129,0.0002218642,0.00006218626,0.0001750083,0.0003096617,0.00005417574,0.0003338016,0.001062747,2.454739e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004064649,"about_ca_system_score_gemma":0.0000617232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001090417,"about_ca_topic_score_gemma":0.000003578893,"domain_scores_codex":[0.9979006,0.0006575843,0.0005767357,0.0003234663,0.0001608285,0.0003807665],"domain_scores_gemma":[0.9991308,0.0002129067,0.0002134286,0.00008172118,0.00003706469,0.000324109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009259849,0.0002963222,0.001060095,0.00005537162,0.0001092837,0.0004424281,0.0003639909,0.00003985476,0.9903499,0.00008255348,0.00008676334,0.006187446],"study_design_scores_gemma":[0.005444066,0.0003761685,0.00891151,0.00001490506,0.0002607938,0.001364864,0.0001242173,0.002812209,0.9718745,0.002535367,0.005942286,0.0003390702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765245,0.02151223,0.00004081457,0.001344254,0.0002630469,0.0002156175,0.00003638917,0.000005099747,0.00005801478],"genre_scores_gemma":[0.9928827,0.004546536,0.000336528,0.002098067,0.00007422025,0.00002185968,0.000003350738,0.00001877895,0.00001792045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01847536,"threshold_uncertainty_score":0.9047359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700171959952816,"score_gpt":0.347044667466597,"score_spread":0.3200429478670688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}