{"id":"W4306404447","doi":"10.3390/v14102272","title":"SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Government of Saskatchewan; Canadian Institutes of Health Research","keywords":"Infectivity; Immune system; Humanized mouse; Biology; Virology; Lung; Viral replication; Virus; Context (archaeology); Immunology; Pathogenesis; Viral pathogenesis; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005600367,0.0002163771,0.0004588571,0.0004186093,0.0002890347,0.00006689571,0.0001772991,0.00008083365,0.0000350134],"category_scores_gemma":[0.0001614515,0.0002084783,0.00007566315,0.0005152269,0.00009971479,0.0002149145,0.0004074698,0.000586239,0.00001973947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002760767,"about_ca_system_score_gemma":0.000221628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001221266,"about_ca_topic_score_gemma":0.000236612,"domain_scores_codex":[0.9981321,0.0001770455,0.0003042865,0.0004758864,0.0004518681,0.0004588269],"domain_scores_gemma":[0.9992074,0.0001459389,0.00009099551,0.0004635508,0.00006485675,0.00002722978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008224217,0.0004488369,0.03921892,0.000132454,0.00004573111,0.000172601,0.0004825556,0.00001839627,0.9571614,0.0003228932,0.0003764888,0.0007973503],"study_design_scores_gemma":[0.003724606,0.0002433685,0.005216117,0.00005588304,0.00002933052,0.0000654486,0.0002686913,0.0146985,0.9610443,0.0004384661,0.01392147,0.0002938851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995613,0.002133714,0.0003017442,0.00006252957,0.00005694263,0.0007975577,0.00005685831,0.000141298,0.0008363712],"genre_scores_gemma":[0.990857,0.00002728305,0.0001671401,0.008404041,0.00005268284,0.0003913949,0.000002607519,0.00005432327,0.000043518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0340028,"threshold_uncertainty_score":0.85015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07073436575273823,"score_gpt":0.3409359047370217,"score_spread":0.2702015389842835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}