{"id":"W4306404447","doi":"10.3390/v14102272","title":"SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Government of Saskatchewan; Canadian Institutes of Health Research","keywords":"Infectivity; Immune system; Humanized mouse; Biology; Virology; Lung; Viral replication; Virus; Context (archaeology); Immunology; Pathogenesis; Viral pathogenesis; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007942481,0.0009895189,0.0005852252,0.0008114498,0.0002409685,0.000778741,0.0004493913,0.0009700938,0.00224382],"category_scores_gemma":[0.0002638479,0.0003516368,0.000469552,0.0002454341,0.000659175,0.0007748422,0.000298964,0.001701427,0.0007247913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004256279,"about_ca_system_score_gemma":0.0002999213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004990739,"about_ca_topic_score_gemma":0.0006875395,"domain_scores_codex":[0.9993864,0.0001369889,0.00006130726,0.0001905712,0.0001253242,0.00009925437],"domain_scores_gemma":[0.9996789,0.00004815169,0.000110706,0.00006455063,0.00002849975,0.00006931615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006686553,0.0003084748,0.0004611388,0.0000436869,0.00001197824,0.00009722857,0.0000362402,0.0001168077,0.9969657,0.0001691121,0.00008857594,0.001032394],"study_design_scores_gemma":[0.0002102025,0.00710352,0.007516657,0.0000326618,0.00007275939,0.00221475,0.0001508063,0.002850155,0.9744757,0.0003003231,0.005039788,0.00003280155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815337,0.001562438,0.01214838,0.0002683876,0.0001059751,0.0002652575,0.001639502,0.0003320013,0.002144354],"genre_scores_gemma":[0.9829778,0.001079304,0.008498684,0.0001487857,0.0000269995,0.000329443,0.001990929,0.00006715021,0.004880958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00224382,"threshold_uncertainty_score":0.007506311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07073436575273823,"score_gpt":0.3409359047370217,"score_spread":0.2702015389842835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}