{"id":"W4306404638","doi":"10.1242/dev.200713","title":"Modeling mammalian spermatogonial differentiation and meiotic initiation<i>in vitro</i>","year":2022,"lang":"en","type":"article","venue":"Development","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institutes of Health; East Carolina University; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Male Contraceptive Initiative","keywords":"Biology; Meiosis; Retinoic acid; Cell biology; In vitro; Cellular differentiation; Genetics; Germ cell; Cell sorting; Homologous recombination; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213744,0.00007108309,0.0001037415,0.0001206689,0.0001213259,0.00001133988,0.00002043475,0.00001950976,0.0001626727],"category_scores_gemma":[0.00002036178,0.00007202599,0.00001507663,0.00009057296,0.000005370935,0.0000390158,0.00004764801,0.0001048452,0.000009940379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174234,"about_ca_system_score_gemma":0.00008564202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001527942,"about_ca_topic_score_gemma":0.00000779428,"domain_scores_codex":[0.9993157,0.00002434588,0.0001794668,0.0001469147,0.0002151666,0.0001183674],"domain_scores_gemma":[0.9998396,0.000009425538,0.00002224015,0.00006274389,0.00001996073,0.00004602114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002604178,0.002538397,0.5780311,0.0008091101,0.0003700731,0.0009162278,0.03409403,0.01877735,0.2245238,0.002572265,0.0007444384,0.1340191],"study_design_scores_gemma":[0.005955755,0.0001304073,0.6657283,0.00006412403,0.0001004052,0.0004589025,0.001106918,0.2970419,0.02446429,0.0003106283,0.004159572,0.0004788699],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965243,0.00006591447,0.002243594,0.0003592891,0.0001856873,0.0001827106,0.000001541715,0.00003039868,0.000406544],"genre_scores_gemma":[0.9973145,0.000004306211,0.001983326,0.000339426,0.00003656752,0.00004619527,0.0001640013,0.000009728181,0.0001020248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2782645,"threshold_uncertainty_score":0.2937135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822498492963133,"score_gpt":0.2275569769017199,"score_spread":0.2093319919720886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}