{"id":"W4306405539","doi":"10.7554/elife.79720","title":"Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"Natural Science Foundation of Zhejiang Province; Vetenskapsrådet; Cancer Research UK; Medical Research Council; Science Fund for Distinguished Young Scholars of Zhejiang Province; Swedish Cancer Foundation","keywords":"Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Mendelian inheritance; Pandemic; Genetics; Betacoronavirus; Medicine; Virology; Internal medicine; Gene; Outbreak; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02335024,0.001207006,0.001668943,0.001549974,0.000850688,0.0009979007,0.001148195,0.0009983311,0.004063183],"category_scores_gemma":[0.04891161,0.0009458169,0.003819573,0.002141673,0.0009135751,0.0005820018,0.001099667,0.0008407668,0.0004929817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006189272,"about_ca_system_score_gemma":0.0007414533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00335811,"about_ca_topic_score_gemma":0.002190328,"domain_scores_codex":[0.9694788,0.01940401,0.003213529,0.005446586,0.001690672,0.0007663395],"domain_scores_gemma":[0.9793087,0.009265967,0.004625454,0.005409798,0.001002482,0.0003876495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02067013,0.0003693987,0.9363569,0.0009414274,0.01950716,0.001239067,0.001018803,0.001033729,0.002443279,0.001020708,0.00164247,0.01375693],"study_design_scores_gemma":[0.009159004,0.008258766,0.9285069,0.0005180637,0.02667414,0.003891563,0.0007300228,0.01080747,0.001903794,0.002386668,0.006981825,0.0001819798],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693832,0.003903699,0.02163428,0.0002123436,0.0001090986,0.001987128,0.001762983,0.0001380051,0.0008693675],"genre_scores_gemma":[0.9928685,0.0002591894,0.004262224,0.0001353567,0.00001992841,0.001210044,0.0009359971,0.00004713752,0.000261688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02335024,"threshold_uncertainty_score":0.1234893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04045363581441763,"score_gpt":0.3406356012873371,"score_spread":0.3001819654729195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}