{"id":"W4306407322","doi":"10.1016/j.neurobiolaging.2022.10.005","title":"Predicting time-to-conversion for dementia of Alzheimer's type using multi-modal deep survival analysis","year":2022,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Memorial University of Newfoundland; University of Victoria; Simon Fraser University","funders":"Alzheimer's Disease Research Center, Wake Forest School of Medicine; Alzheimer Society of B.C.; Canadian Institutes of Health Research; National Institute on Aging; Alzheimer Society Research Program; Wake Forest School of Medicine; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; University of Nottingham; Alzheimer Society; Michael Smith Health Research BC; U.S. Department of Defense; Eli Lilly and Company; Compute Canada; Peer Reviewed Alzheimer’s Research Program; Northern California Institute for Research and Education; Natural Sciences and Engineering Research Council of Canada; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Bristol-Myers Squibb; Fondation Brain Canada; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Dementia; Neuroimaging; Cognition; Alzheimer's disease; Alzheimer's Disease Neuroimaging Initiative; Disease; Medicine; Audiology; Psychology; Neuroscience; Artificial intelligence; Internal medicine; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001183059,0.0005580724,0.0005741289,0.0008805706,0.0002274774,0.0006951824,0.0004179699,0.0005497634,0.001275787],"category_scores_gemma":[0.003235876,0.0001445686,0.0007551609,0.0003773353,0.0001535833,0.0004934378,0.0006255771,0.0009975662,0.0003051478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003326848,"about_ca_system_score_gemma":0.0005322361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007199416,"about_ca_topic_score_gemma":0.009439508,"domain_scores_codex":[0.9998152,0.00004093356,0.00002010445,0.00004929131,0.00002082753,0.0000536667],"domain_scores_gemma":[0.9991098,0.0004099239,0.0001272877,0.00008367607,0.0001363058,0.0001330574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002498796,0.000591135,0.8223144,0.00009560487,0.0007868552,0.0004414561,0.0001269492,0.04384679,0.002652218,0.000943754,0.004516752,0.1211853],"study_design_scores_gemma":[0.00007860055,0.0007639737,0.3226498,0.00008364177,0.0005345521,0.0008770697,0.000271681,0.6636618,0.001978072,0.007695154,0.001322719,0.00008285564],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849332,0.0006423531,0.01103424,0.0003652594,0.00005312007,0.00001489357,0.002305967,0.0001167237,0.0005342055],"genre_scores_gemma":[0.9956138,0.0001509846,0.001664328,0.00003892816,0.00002292006,0.00001001386,0.002086943,0.000006366979,0.0004056736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007199416,"threshold_uncertainty_score":0.01431501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03998961488744913,"score_gpt":0.332770239570602,"score_spread":0.2927806246831529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}