{"id":"W4306407989","doi":"10.1101/2022.10.13.511954","title":"A human DCC variant causing mirror movement disorder reveals an essential role for the Wave regulatory complex in Netrin/DCC signaling","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; McGill University Health Centre; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Science Foundation","keywords":"Netrin; Axon guidance; Deleted in Colorectal Cancer; Biology; Axon; Cell biology; Genetics; Neuroscience; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233474,0.0008286861,0.0003186864,0.0006043458,0.0003788703,0.0003648834,0.0002872747,0.001012738,0.001805401],"category_scores_gemma":[0.0004991654,0.0001539157,0.0002832407,0.0002732492,0.0005330914,0.0001158351,0.0003464747,0.000786515,0.0003122873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005354982,"about_ca_system_score_gemma":0.0002952064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003553765,"about_ca_topic_score_gemma":0.002655426,"domain_scores_codex":[0.9998046,0.00001713294,0.0000227264,0.00007209938,0.00005553992,0.00002795435],"domain_scores_gemma":[0.9997527,0.00007321603,0.00005805702,0.00001618344,0.00002400067,0.00007595438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001299124,0.0002587856,0.04153635,0.0001150768,0.0001562076,0.1499204,0.0003204423,0.001197035,0.7884361,0.002701666,0.002194548,0.0118642],"study_design_scores_gemma":[0.0003417903,0.0007944359,0.2802876,0.00009851276,0.0003182549,0.3538082,0.0004570959,0.01762535,0.3295993,0.00257367,0.01398556,0.0001103026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964665,0.0002857363,0.001190143,0.0003363085,0.00005749981,0.00002295493,0.000424903,0.00004893036,0.001166997],"genre_scores_gemma":[0.9975973,0.00007793219,0.001214889,0.0001240503,0.00002706716,0.000006693096,0.0003144551,0.00002194938,0.0006156081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003553765,"threshold_uncertainty_score":0.00706619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05036460902172075,"score_gpt":0.2771039593548535,"score_spread":0.2267393503331328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}