{"id":"W4306409445","doi":"10.1096/fj.202201263r","title":"Early‐immediate gene Egr1 is associated with <scp>TGFβ1</scp> regulation of epigenetic reader Bromodomain‐containing protein 4 via the canonical Smad3 signaling in hepatic stellate cells in vitro and in vivo","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Liver physiology and pathology","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Natural Science Foundation of China","keywords":"Gene knockdown; Bromodomain; Hepatic stellate cell; EGR1; Epigenetics; BRD4; Cancer research; Biology; Transforming growth factor; Downregulation and upregulation; JUNB; Cell biology; Signal transduction; Thioacetamide; Gene expression; Apoptosis; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001953642,0.0001467181,0.0004113945,0.000182589,0.0001633122,0.000009628934,0.0001449069,0.00009923895,0.0000607341],"category_scores_gemma":[0.0000905139,0.00009313197,0.00004772558,0.0003506014,0.0001809041,0.00004740563,0.00007719289,0.001020379,0.000001193096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000154672,"about_ca_system_score_gemma":0.0001938688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002778836,"about_ca_topic_score_gemma":0.0001164275,"domain_scores_codex":[0.9973544,0.001341561,0.0004943257,0.0001925211,0.0002659957,0.0003511578],"domain_scores_gemma":[0.9987735,0.0006116757,0.0003345175,0.0001751773,0.00004197652,0.00006313719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007358724,0.00009425624,0.04055587,0.00001339172,0.00006282378,0.000283582,0.009412189,0.002579762,0.9461284,0.000003390763,0.000003308133,0.0001271193],"study_design_scores_gemma":[0.004248602,0.0009524499,0.3159641,0.0002138274,0.0001022214,0.0004452936,0.001612157,0.004201442,0.6708564,0.001317274,0.000002459934,0.00008385632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987256,0.0003352953,0.00004553252,0.0002712773,0.00005233687,0.000516945,0.00001214204,0.000005192169,0.00003565675],"genre_scores_gemma":[0.999445,0.0000247167,0.0001195188,0.0002278866,0.00005138416,0.00002609902,0.00000673572,0.00001955757,0.00007905652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2754082,"threshold_uncertainty_score":0.4433097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520113883913876,"score_gpt":0.2222508763670338,"score_spread":0.207049737527895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}