{"id":"W4306409445","doi":"10.1096/fj.202201263r","title":"Early‐immediate gene Egr1 is associated with <scp>TGFβ1</scp> regulation of epigenetic reader Bromodomain‐containing protein 4 via the canonical Smad3 signaling in hepatic stellate cells in vitro and in vivo","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Liver physiology and pathology","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Natural Science Foundation of China","keywords":"Gene knockdown; Bromodomain; Hepatic stellate cell; EGR1; Epigenetics; BRD4; Cancer research; Biology; Transforming growth factor; Downregulation and upregulation; JUNB; Cell biology; Signal transduction; Thioacetamide; Gene expression; Apoptosis; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001744117,0.0002677959,0.0001753027,0.0002304338,0.0001443241,0.0002064532,0.000109945,0.0001476222,0.001592778],"category_scores_gemma":[0.000067489,0.0001738718,0.0002862902,0.0001099252,0.0002567642,0.00009709669,0.0001880669,0.0004378817,0.0005710631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002078173,"about_ca_system_score_gemma":0.0001646559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005253669,"about_ca_topic_score_gemma":0.0007687492,"domain_scores_codex":[0.9998335,0.00003475929,0.00001380708,0.0000343293,0.00004001937,0.00004349977],"domain_scores_gemma":[0.999911,0.00001195702,0.00003187095,0.00001173173,0.000008361816,0.00002515688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007585619,0.000008930575,0.00009660201,0.00001670286,0.000002524313,0.00002656659,0.000006462853,0.00001456215,0.9994778,0.00003641196,0.00001725302,0.0002203535],"study_design_scores_gemma":[0.00001455198,0.0001126158,0.006852123,0.000004041663,0.000009175035,0.0001760686,0.00003312759,0.0004753074,0.9908502,0.00003637778,0.001433902,0.000002510766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937982,0.001406502,0.002809396,0.0001262307,0.00003508605,0.00001796565,0.0003167613,0.00009548707,0.001394419],"genre_scores_gemma":[0.9950127,0.0005958384,0.001060262,0.00008538816,0.000008980068,0.00002481255,0.0004917223,0.00002138351,0.002698882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592778,"threshold_uncertainty_score":0.005328417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520113883913876,"score_gpt":0.2222508763670338,"score_spread":0.207049737527895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}