{"id":"W4306411715","doi":"10.1038/s41591-022-02023-7","title":"Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institutes of Health; Novo Nordisk Fonden; Aalborg Universitetshospital; Aarhus Universitet; Aalborg Universitet; Odense Universitetshospital; Michael Smith Health Research BC; Government of Canada; Gentofte Hospital; Canadian Institutes of Health Research; Danmarks Frie Forskningsfond; Imperial College London; Sundhed og Sygdom, Det Frie Forskningsråd; National Institute of Allergy and Infectious Diseases; Medical Research Council; Celgene; Aarhus Universitetshospital; King's College London; Bristol-Myers Squibb","keywords":"Romidepsin; Intervention (counseling); Human immunodeficiency virus (HIV); Medicine; Randomized controlled trial; Antiretroviral therapy; Family medicine; Internal medicine; Psychiatry; Viral load; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005385092,0.0001966783,0.0006223044,0.0002700734,0.0002051114,0.000007732282,0.0000719293,0.000128029,0.0007280973],"category_scores_gemma":[0.00009836342,0.0001105535,0.00005966873,0.0002078115,0.0002292371,0.00006868109,0.00005034128,0.0005076303,0.00002215495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003284277,"about_ca_system_score_gemma":0.00005867236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123106,"about_ca_topic_score_gemma":0.001434001,"domain_scores_codex":[0.9983186,0.0006806334,0.0002739579,0.0003193324,0.0001306575,0.0002768891],"domain_scores_gemma":[0.9993488,0.0002724414,0.000136843,0.0001651038,0.00003683281,0.00003999886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9769038,0.001741818,0.009001662,0.00001668593,0.0004540372,0.0002283187,0.002394762,0.000001539506,0.002064103,0.00007097405,0.0004541992,0.006668132],"study_design_scores_gemma":[0.9663263,0.025087,0.004392897,0.00006595952,0.0002009686,0.0001336889,0.0003575594,0.00001077422,0.001133782,0.00001759086,0.002159843,0.0001136219],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898364,0.006628491,0.00003745185,0.001124364,0.0002009607,0.001697414,0.00009257102,0.00002902538,0.0003533346],"genre_scores_gemma":[0.9949767,0.0001380729,0.00002519111,0.000064757,0.00004850791,0.0005641946,0.001767504,0.00001466036,0.002400429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02334518,"threshold_uncertainty_score":0.7972155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008217535099714051,"score_gpt":0.2886374964761343,"score_spread":0.2804199613764202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}