{"id":"W4306411715","doi":"10.1038/s41591-022-02023-7","title":"Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institutes of Health; Novo Nordisk Fonden; Aalborg Universitetshospital; Aarhus Universitet; Aalborg Universitet; Odense Universitetshospital; Michael Smith Health Research BC; Government of Canada; Gentofte Hospital; Canadian Institutes of Health Research; Danmarks Frie Forskningsfond; Imperial College London; Sundhed og Sygdom, Det Frie Forskningsråd; National Institute of Allergy and Infectious Diseases; Medical Research Council; Celgene; Aarhus Universitetshospital; King's College London; Bristol-Myers Squibb","keywords":"Romidepsin; Intervention (counseling); Human immunodeficiency virus (HIV); Medicine; Randomized controlled trial; Antiretroviral therapy; Family medicine; Internal medicine; Psychiatry; Viral load; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002775485,0.001703885,0.003116454,0.0005920846,0.0006005825,0.001250023,0.0008358218,0.002650647,0.004682576],"category_scores_gemma":[0.002639065,0.0007557257,0.002404971,0.00039831,0.001339186,0.001036088,0.0005697802,0.002413035,0.0005320006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007788115,"about_ca_system_score_gemma":0.001495791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001436664,"about_ca_topic_score_gemma":0.002274787,"domain_scores_codex":[0.9982132,0.001122679,0.0001190628,0.0002236788,0.0001066314,0.0002147853],"domain_scores_gemma":[0.9986143,0.000527608,0.0002919034,0.0001092996,0.00008578669,0.0003710956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9828308,0.00828469,0.0002502934,0.000293058,0.0003743232,0.00001835507,0.00003550036,0.0001274316,0.0009285281,0.00005171651,0.0001520291,0.006653308],"study_design_scores_gemma":[0.9388779,0.05966439,0.0005941806,0.00002118841,0.000231567,0.00001067636,0.00001349636,0.0002012286,0.0001748745,0.00005493195,0.0001473519,0.000008303725],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904891,0.002342315,0.0005279432,0.0003754039,0.00050454,0.004450693,0.0003250905,0.0000669677,0.0009178627],"genre_scores_gemma":[0.9849129,0.001949887,0.002579153,0.001070476,0.0006365725,0.00647918,0.0004438372,0.00001838098,0.001909574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004682576,"threshold_uncertainty_score":0.01566476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008217535099714051,"score_gpt":0.2886374964761343,"score_spread":0.2804199613764202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}