{"id":"W4306412026","doi":"10.1158/0008-5472.can-22-1123","title":"The 5-Hydroxymethylcytosine Landscape of Prostate Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Princess Margaret Cancer Centre; University of Toronto; Spinal Cord Injury BC; University of British Columbia","funders":"National Cancer Institute; National Human Genome Research Institute; Canadian Institutes of Health Research; Jane ja Aatos Erkon Säätiö; Stand Up To Cancer; National Institutes of Health; University of Wisconsin Carbone Cancer Center; Svenska Läkaresällskapet; Safeway Foundation; Prostate Cancer Canada; Vetenskapsrådet; Prostate Cancer Foundation; American Association for Cancer Research; Movember Foundation","keywords":"Cancer; 5-Hydroxymethylcytosine; Prostate; Biology; Medicine; Physiology; Internal medicine; Genetics; DNA methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430349,0.000134601,0.0001351154,0.0004523055,0.0001956672,0.0003341582,0.0001427012,0.0002087481,0.0007984343],"category_scores_gemma":[0.000167773,0.0001080787,0.00009948287,0.000389395,0.0002312274,0.00013864,0.0001850602,0.0002506303,0.0002038561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003897489,"about_ca_system_score_gemma":0.0002989931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00353257,"about_ca_topic_score_gemma":0.005769569,"domain_scores_codex":[0.9998989,0.00001781023,0.000002957244,0.00003489322,0.00002806713,0.00001744321],"domain_scores_gemma":[0.9999403,0.00001100947,0.00001601113,0.000006471605,0.000016367,0.000009989349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001647347,0.00001141906,0.01845613,0.0001842753,0.00005578365,0.00008737652,0.0001121177,0.0007740942,0.9399091,0.000829778,0.0005025707,0.0389127],"study_design_scores_gemma":[0.00001118993,0.0004337328,0.446582,0.00005255111,0.0001450313,0.001809653,0.0003300008,0.004659375,0.5122247,0.003095254,0.03060677,0.00004969052],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9217173,0.04908678,0.0170893,0.0007998053,0.00006174599,0.00004760738,0.003486663,0.0003733827,0.007337397],"genre_scores_gemma":[0.9875541,0.006880605,0.003088514,0.0001689848,0.00002667691,0.00001396636,0.0007511105,0.00002046352,0.00149554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00353257,"threshold_uncertainty_score":0.00702399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03686843628494731,"score_gpt":0.3801408490908182,"score_spread":0.3432724128058709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}