{"id":"W4306412026","doi":"10.1158/0008-5472.can-22-1123","title":"The 5-Hydroxymethylcytosine Landscape of Prostate Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Princess Margaret Cancer Centre; University of Toronto; Spinal Cord Injury BC; University of British Columbia","funders":"National Cancer Institute; National Human Genome Research Institute; Canadian Institutes of Health Research; Jane ja Aatos Erkon Säätiö; Stand Up To Cancer; National Institutes of Health; University of Wisconsin Carbone Cancer Center; Svenska Läkaresällskapet; Safeway Foundation; Prostate Cancer Canada; Vetenskapsrådet; Prostate Cancer Foundation; American Association for Cancer Research; Movember Foundation","keywords":"Cancer; 5-Hydroxymethylcytosine; Prostate; Biology; Medicine; Physiology; Internal medicine; Genetics; DNA methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001069507,0.00005811469,0.00006940619,0.00004575356,0.0004394471,0.00001766166,0.0002712158,0.00002933979,0.0001992246],"category_scores_gemma":[0.00006328151,0.00004433747,0.00003925752,0.0002739509,0.0001211519,0.000001271273,0.000311139,0.0001906407,0.000001313462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003289519,"about_ca_system_score_gemma":0.0002813042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003047749,"about_ca_topic_score_gemma":0.0002145798,"domain_scores_codex":[0.9987733,0.0002359267,0.0001366991,0.0001996908,0.00039257,0.0002618083],"domain_scores_gemma":[0.9993687,0.00004324874,0.00005042095,0.0002877004,0.0002058705,0.00004411409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001682489,0.00002553451,0.009777858,0.00001282562,0.00003887354,7.216831e-7,0.0001181404,0.001727416,0.9655843,0.0000978363,0.005552102,0.01689614],"study_design_scores_gemma":[0.0002719991,0.0002162002,0.001768435,0.000003479998,0.000003886041,2.99003e-7,0.0001768557,0.0000738797,0.6272313,0.0002440689,0.3699486,0.00006096707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9532315,0.04441097,0.00001246814,0.0009636353,0.0001660655,0.000224047,0.00007487796,0.000002928758,0.0009134759],"genre_scores_gemma":[0.9857783,0.009474679,0.00001511131,0.00002617136,0.0001661735,0.0004985109,0.00002937919,0.00001639774,0.003995305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3643965,"threshold_uncertainty_score":0.3379916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03686843628494731,"score_gpt":0.3801408490908182,"score_spread":0.3432724128058709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}