{"id":"W4306639137","doi":"10.1101/2022.10.16.22280490","title":"Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Center for Advancing Translational Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; Junta de Castilla y León; Génome Québec; Conseil Régional des Pays de la Loire; National Institutes of Health; Centre Hospitalier Universitaire de Nantes; Medizinische Universität Graz; Grantová Agentura České Republiky; Herzfelder'sche Familienstiftung; Institut Gustave-Roussy; School of Public Health, Imperial College London; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Ministerstvo Zdravotnictví Ceské Republiky; Canadian Institutes of Health Research; Cancerfonden; Johns Hopkins University; Centre International de Recherche sur le Cancer; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Centres de Recerca de Catalunya; Imperial College London; Generalitat de Catalunya; Food Standards Agency; Swedish Cancer Foundation; Damon Runyon Cancer Research Foundation; Karl-Franzens-Universität Graz; Univerzita Karlova v Praze; McGill University; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Fred Hutchinson Cancer Research Center; Brigham and Women's Hospital; Emory University; Cancer Research UK; American Cancer Society; U.S. Department of Health and Human Services","keywords":"Colorectal cancer; Diabetes mellitus; Genome-wide association study; Cancer; Gene; Oncology; Type 2 diabetes; Immune system; Biology; Internal medicine; Cancer research; Medicine; Bioinformatics; Genetics; Endocrinology; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003453847,0.0006843442,0.0008584988,0.002003901,0.0004593311,0.001024283,0.0005591164,0.0005504353,0.005204663],"category_scores_gemma":[0.006129087,0.0003082622,0.002019537,0.002171943,0.000472915,0.0002953404,0.001039235,0.0009948162,0.0003516791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003082657,"about_ca_system_score_gemma":0.0004415729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003385935,"about_ca_topic_score_gemma":0.003459323,"domain_scores_codex":[0.9956763,0.002960371,0.0001387418,0.0005967178,0.0003500039,0.0002777643],"domain_scores_gemma":[0.9929941,0.005591715,0.0006185998,0.0004570399,0.0001068515,0.0002316188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003455608,0.0002531476,0.9122986,0.0003028186,0.01054284,0.001654389,0.0002123584,0.00528031,0.03226997,0.002014508,0.002711943,0.02900355],"study_design_scores_gemma":[0.000232307,0.0008813288,0.9593967,0.00003257238,0.003875355,0.001194737,0.0002623899,0.01804649,0.00635774,0.005604071,0.004049724,0.00006664002],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589553,0.001963162,0.02999748,0.0008942652,0.00009264069,0.00004894866,0.005640435,0.0004594761,0.001948425],"genre_scores_gemma":[0.987007,0.0002663854,0.009834914,0.0001616836,0.00005833173,0.00005144454,0.001809218,0.00006407929,0.000746941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005204663,"threshold_uncertainty_score":0.0182659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05798129609930337,"score_gpt":0.3251585067530868,"score_spread":0.2671772106537835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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