{"id":"W4306655136","doi":"10.21203/rs.3.rs-2160180/v1","title":"Integrative transcriptomic and proteomic analysis show circulating osteoprogenitors to have a mixed immune and mesenchymal progenitor function in humans","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute on Aging; National Institutes of Health; Australian Institute for Musculoskeletal Science; Australian Government; University of South Carolina; Medical University of South Carolina; U.S. Department of Veterans Affairs","keywords":"Mesenchymal stem cell; Immune system; Transcriptome; Progenitor cell; Biology; Function (biology); Progenitor; Computational biology; Cell biology; Immunology; Stem cell; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002298058,0.0002212676,0.0002116057,0.0003582949,0.0001886823,0.0005856368,0.0001338739,0.000317052,0.001702445],"category_scores_gemma":[0.0003466214,0.000191391,0.0001962638,0.0002489869,0.0002633465,0.0001643026,0.0001804422,0.0003170904,0.0003561085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001086762,"about_ca_system_score_gemma":0.0001544514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007736292,"about_ca_topic_score_gemma":0.0005554593,"domain_scores_codex":[0.9998814,0.00001339272,0.000007050164,0.00005692475,0.00002501294,0.00001620971],"domain_scores_gemma":[0.9998993,0.00002976328,0.00002635794,0.00001670607,0.00001352571,0.00001444943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003823132,0.0001614945,0.1663133,0.0001941478,0.0002805744,0.001971516,0.0007992014,0.000461337,0.7662818,0.001005164,0.001850099,0.05685832],"study_design_scores_gemma":[0.00005067479,0.0004953427,0.9200231,0.00003462414,0.0002499408,0.004516438,0.0005281447,0.0008613798,0.06668615,0.001274725,0.005254942,0.00002443819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944819,0.001271631,0.001743785,0.0001555624,0.00002539899,0.000009520607,0.00125752,0.00002968865,0.001025125],"genre_scores_gemma":[0.9940655,0.0007152678,0.00149091,0.0002255383,0.00004079796,0.00002157554,0.001299282,0.00002579475,0.002115272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702445,"threshold_uncertainty_score":0.005695283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06576019874160152,"score_gpt":0.3940566750651462,"score_spread":0.3282964763235448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}