{"id":"W4306661079","doi":"10.1200/jco.22.01207","title":"Identification of Patients With Ovarian Cancer Experiencing the Highest Benefit From Bevacizumab in the First-Line Setting on the Basis of Their Tumor-Intrinsic Chemosensitivity (KELIM): The GOG-0218 Validation Study","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Cancer Center, University of Colorado; Walter Reed National Military Medical Center; SUNY Downstate Medical Center; Cancer Institute, University of Pittsburgh; University of Oklahoma Health Sciences Center; Medical Center, University of Pittsburgh; University of Texas MD Anderson Cancer Center; EMD Serono; Saitama Medical University; Clovis Oncology; Seoul National University Hospital; Case Western Reserve University; Celldex Therapeutics; Exelixis; Regeneron Pharmaceuticals; Ludwig Institute for Cancer Research; Astellas Pharma; University of Oklahoma; Eisai; Virginia Commonwealth University; Barbara Ann Karmanos Cancer Institute; Stryker; AstraZeneca; Genentech; University of Cincinnati; Pennsylvania State University; GlaxoSmithKline; Stony Brook University; University of Pittsburgh; University of Minnesota; Roswell Park Cancer Institute; Cleveland Clinic Foundation; Brody School of Medicine; Bristol-Myers Squibb; York University; Moffitt Cancer Center; Cleveland Clinic; Array BioPharma; Ohio State University; Wake Forest University; NRG Oncology; Memorial Sloan-Kettering Cancer Center; Rush University; Amgen; University of Pennsylvania; University of North Carolina at Chapel Hill; Wayne State University; PharmaMar; Northwestern University; Seoul National University; Yale University; Sanofi; Edwards Lifesciences; Pfizer","keywords":"Medicine; Bevacizumab; Internal medicine; Hazard ratio; Oncology; Ovarian cancer; Carboplatin; Progression-free survival; Placebo; Clinical endpoint; Cancer; Chemotherapy; Randomized controlled trial; Pathology; Cisplatin; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001503008,0.0007552807,0.0007598121,0.0003289472,0.000189309,0.0005710579,0.0004863527,0.0005542699,0.0009719845],"category_scores_gemma":[0.001940762,0.0002505204,0.0007786171,0.0002480446,0.0004399675,0.0003953422,0.0003937244,0.0006327421,0.0002306452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004397335,"about_ca_system_score_gemma":0.0004314139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004355646,"about_ca_topic_score_gemma":0.000708202,"domain_scores_codex":[0.9995781,0.0001960452,0.00001993555,0.00009713461,0.00005162766,0.00005728062],"domain_scores_gemma":[0.9989604,0.0002662492,0.0003668444,0.0001397042,0.00004762617,0.0002191029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04506715,0.00191475,0.9296478,0.0001003763,0.0009844592,0.0001620886,0.00008527103,0.0007475398,0.003890679,0.0000804589,0.0008328608,0.01648664],"study_design_scores_gemma":[0.01339562,0.01756784,0.9600811,0.00002916727,0.0008132889,0.0008333945,0.00007320437,0.00319852,0.001827828,0.0002107469,0.001939451,0.00002981775],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991751,0.0002510987,0.000088939,0.00003137122,0.00000435605,0.00006562743,0.0002017869,0.000005080373,0.0001765554],"genre_scores_gemma":[0.998353,0.00007802217,0.0001702509,0.00007512698,0.00002101086,0.00005938558,0.001094104,0.00000340081,0.0001456326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503008,"threshold_uncertainty_score":0.007948756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06551143553526073,"score_gpt":0.3779583636623471,"score_spread":0.3124469281270864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}