{"id":"W4306663866","doi":"10.1002/alz.12800","title":"Metabolomic and lipidomic signatures in autosomal dominant and late‐onset Alzheimer's disease brains","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Genentech; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Denali Therapeutics; GHR Foundation; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Hope Center for Neurological Disorders; University of Southern California; AstraZeneca; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Cure Alzheimer's Fund; Meso Scale Diagnostics; Sanofi; FONDATION ALZHEIMER; Alzheimer's Association; Novartis Pharmaceuticals Corporation; Amgen","keywords":"PSEN1; TREM2; Metabolome; Metabolomics; Disease; Biology; Genetics; Neurodegeneration; Metabolite; Alzheimer's disease; Bioinformatics; Medicine; Presenilin; Internal medicine; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002708448,0.0002419512,0.0002210531,0.0002422816,0.0004955085,0.0001140926,0.000228712,0.00003534344,0.0004457875],"category_scores_gemma":[0.00006958529,0.0002495763,0.00005380799,0.0002586218,0.0001049318,0.0002786745,0.0003884926,0.0002870745,0.00001725612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004122167,"about_ca_system_score_gemma":0.00006579608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001230891,"about_ca_topic_score_gemma":0.00001603391,"domain_scores_codex":[0.9977309,0.0005107936,0.0003643594,0.0007090197,0.0003406527,0.0003443226],"domain_scores_gemma":[0.9992114,0.0001548961,0.0001385323,0.0002818402,0.00001157322,0.0002017247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003474286,0.0001805728,0.001057819,0.000004471977,0.0002904754,0.0002206249,0.0004276076,0.001048584,0.9810347,0.008768449,0.001531901,0.005087347],"study_design_scores_gemma":[0.002745812,0.0001906416,0.02638784,0.000006337687,0.002856865,0.00006175692,0.00005453521,0.01860321,0.9305387,0.001541845,0.01632935,0.0006831227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795771,0.01736544,0.00002625592,0.001557186,0.0006117537,0.0005935798,0.00008567007,0.00008871848,0.00009433374],"genre_scores_gemma":[0.9960667,0.0002329433,0.0001473281,0.003300961,0.00004457788,0.0001253182,0.0000122805,0.00003624628,0.00003359443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05049603,"threshold_uncertainty_score":0.9999956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02502975169096898,"score_gpt":0.2543199538988712,"score_spread":0.2292902022079022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}