{"id":"W4306663866","doi":"10.1002/alz.12800","title":"Metabolomic and lipidomic signatures in autosomal dominant and late‐onset Alzheimer's disease brains","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Genentech; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Denali Therapeutics; GHR Foundation; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Hope Center for Neurological Disorders; University of Southern California; AstraZeneca; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Cure Alzheimer's Fund; Meso Scale Diagnostics; Sanofi; FONDATION ALZHEIMER; Alzheimer's Association; Novartis Pharmaceuticals Corporation; Amgen","keywords":"PSEN1; TREM2; Metabolome; Metabolomics; Disease; Biology; Genetics; Neurodegeneration; Metabolite; Alzheimer's disease; Bioinformatics; Medicine; Presenilin; Internal medicine; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001888014,0.0003700123,0.0003877087,0.001423643,0.0002255901,0.0004744823,0.0001099356,0.0002466998,0.0009861153],"category_scores_gemma":[0.0002795351,0.0001126433,0.0002570003,0.0007165444,0.0001619118,0.0002418041,0.0004632479,0.0002119195,0.0001563239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001871666,"about_ca_system_score_gemma":0.0001480907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009211931,"about_ca_topic_score_gemma":0.001199404,"domain_scores_codex":[0.9999195,0.000011868,0.000007588975,0.0000247303,0.00001642102,0.00001977056],"domain_scores_gemma":[0.9998738,0.00001691805,0.00004907515,0.000008846902,0.00002396392,0.0000274124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006804947,0.0001889436,0.21333,0.0004433986,0.0008458098,0.001835036,0.0005905509,0.0004259472,0.7329462,0.0002946064,0.0009225687,0.04137202],"study_design_scores_gemma":[0.00003650666,0.0005458108,0.9626522,0.00004783025,0.0002848316,0.002280249,0.0004712769,0.001167909,0.03004366,0.0007734422,0.001658257,0.00003801367],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949244,0.001929803,0.0005744864,0.00007425773,0.000009232252,0.00001689023,0.001967173,0.00002733382,0.0004762876],"genre_scores_gemma":[0.9942037,0.001236585,0.001465531,0.0001024883,0.00001521617,0.00004015444,0.002379762,0.00001246303,0.0005440671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001423643,"threshold_uncertainty_score":0.003298938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02502975169096898,"score_gpt":0.2543199538988712,"score_spread":0.2292902022079022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}