{"id":"W4306682604","doi":"10.1242/dmm.049349","title":"Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models","year":2022,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Oxford Martin School, University of Oxford; Dementias Platform UK; Innovative Medicines Initiative; Medical Research Council; Cardiff University; University of Oxford; Parkinson's UK; European Federation of Pharmaceutical Industries and Associations; Stem Cell Network; UK Dementia Research Institute; National Institute for Health and Care Research; NIHR Oxford Biomedical Research Centre; Alzheimer's Society; Wellcome Trust","keywords":"Microglia; Induced pluripotent stem cell; Transcriptome; Lipopolysaccharide; Biology; Neuroscience; Neuroinflammation; Innate immune system; Pathogenesis; Reprogramming; Cell biology; Immune system; Gene; Immunology; Inflammation; Genetics; Gene expression; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003211698,0.0008027831,0.0005575416,0.0005393966,0.002074957,0.0004123968,0.001514127,0.00007038542,0.0009170339],"category_scores_gemma":[0.00009018555,0.0009186533,0.0004823894,0.0005489521,0.00009105214,0.00111106,0.000680243,0.0005388982,0.0001664375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000189875,"about_ca_system_score_gemma":0.0002695034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001425782,"about_ca_topic_score_gemma":0.00001848365,"domain_scores_codex":[0.9930559,0.0008291423,0.0008923109,0.002358075,0.001792987,0.001071614],"domain_scores_gemma":[0.9959895,0.0001206914,0.0002971912,0.001452245,0.0001233375,0.002017011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007298333,0.0004067741,0.000002072398,0.00001224627,0.00002391833,0.0002599863,0.0005319972,0.06511268,0.788507,0.1433144,0.0009172334,0.0001818445],"study_design_scores_gemma":[0.0009689535,0.0001379874,0.0000093078,0.00001390095,0.0001991538,0.000003895948,0.0001147937,0.1303281,0.7123432,0.154654,0.0004259779,0.0008006989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7932758,0.0001937463,0.1935413,0.002143442,0.00114083,0.00218736,0.00633925,0.0009715339,0.0002068019],"genre_scores_gemma":[0.9842944,0.00002862963,0.001564378,0.01053734,0.0001551832,0.001255716,0.0003205343,0.000250677,0.001593158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1919769,"threshold_uncertainty_score":0.9999962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06734188426750227,"score_gpt":0.2767330507436511,"score_spread":0.2093911664761488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}