{"id":"W4306684758","doi":"10.1002/pro.4477","title":"Probing the origin of prion protein misfolding via reconstruction of ancestral proteins","year":2022,"lang":"en","type":"article","venue":"Protein Science","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Alliance de recherche numérique du Canada; National Science Foundation of Sri Lanka; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; National Science Foundation","keywords":"Biology; Bovine spongiform encephalopathy; Chronic wasting disease; Amniote; Prion protein; Most recent common ancestor; Evolutionary biology; Primate; Virology; Genetics; Phylogenetics; Vertebrate; Disease; Scrapie; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004428933,0.0004199102,0.0003095371,0.0005090039,0.0003262557,0.0006954343,0.0004453952,0.0006012594,0.0008943693],"category_scores_gemma":[0.001345416,0.0003267154,0.0005098162,0.000491791,0.0003350862,0.0006741828,0.0003813595,0.0009252147,0.0003893065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004077575,"about_ca_system_score_gemma":0.0002856516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105605,"about_ca_topic_score_gemma":0.001337274,"domain_scores_codex":[0.9998983,0.00003146601,0.000006677577,0.00002592815,0.00002182193,0.00001583385],"domain_scores_gemma":[0.9997032,0.0001012269,0.00007049557,0.00004078562,0.00004910091,0.00003513403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009926265,0.0002550949,0.1005284,0.0007653657,0.0004596652,0.003243301,0.001322488,0.1576495,0.6845167,0.01517217,0.0008408953,0.03425384],"study_design_scores_gemma":[0.000103122,0.0009457456,0.1119936,0.0002130039,0.0004415223,0.002846743,0.001360571,0.7577837,0.09348092,0.01136265,0.01935044,0.00011806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864944,0.0003898722,0.01127848,0.00009037768,0.00001432892,0.0000121773,0.000390642,0.00008553394,0.001244027],"genre_scores_gemma":[0.9801711,0.0005503556,0.01729182,0.00003814026,0.00000661533,0.00001462802,0.001463287,0.000078459,0.0003855819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105605,"threshold_uncertainty_score":0.002991974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01763349713965739,"score_gpt":0.2657458522208012,"score_spread":0.2481123550811438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}