{"id":"W4306684758","doi":"10.1002/pro.4477","title":"Probing the origin of prion protein misfolding via reconstruction of ancestral proteins","year":2022,"lang":"en","type":"article","venue":"Protein Science","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Alliance de recherche numérique du Canada; National Science Foundation of Sri Lanka; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; National Science Foundation","keywords":"Biology; Bovine spongiform encephalopathy; Chronic wasting disease; Amniote; Prion protein; Most recent common ancestor; Evolutionary biology; Primate; Virology; Genetics; Phylogenetics; Vertebrate; Disease; Scrapie; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00163583,0.0001376167,0.000158596,0.0001010001,0.0005409928,0.00002738318,0.0007314337,0.00003940518,0.00006156757],"category_scores_gemma":[0.0002099737,0.0001115331,0.0001016626,0.0006781435,0.0005687355,0.00002770408,0.0003985187,0.0001583772,9.351151e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000510989,"about_ca_system_score_gemma":0.0004157067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008056492,"about_ca_topic_score_gemma":0.000004733723,"domain_scores_codex":[0.9982148,0.000152613,0.000385945,0.0004368966,0.0004910604,0.0003186189],"domain_scores_gemma":[0.9988934,0.000006158668,0.0004427859,0.0004591968,0.000128284,0.00007016081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008493473,0.00004450256,0.0005866497,0.00005539415,0.000006435444,4.683866e-7,0.00009478827,0.0002175402,0.9411013,0.0003222222,0.000005202066,0.05748055],"study_design_scores_gemma":[0.0002454662,0.0003919163,0.000358103,0.00007043938,0.000006520572,0.00002291986,0.0001638884,0.0003906715,0.9952581,0.0007681689,0.002175056,0.0001487642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924287,0.001777142,0.003112062,0.0001357677,0.0001029969,0.002299216,0.00001260104,0.00001184637,0.0001197292],"genre_scores_gemma":[0.9936752,0.00003443274,0.005384753,0.00001740384,0.00006442217,0.0007272603,0.000003944282,0.00001156073,0.00008100067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05733178,"threshold_uncertainty_score":0.4548189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01763349713965739,"score_gpt":0.2657458522208012,"score_spread":0.2481123550811438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}