{"id":"W4306697786","doi":"10.1016/j.contraception.2022.10.004","title":"Tolerability and safety of the estetrol/drospirenone combined oral contraceptive: Pooled analysis of two multicenter, open-label phase 3 trials","year":2022,"lang":"en","type":"article","venue":"Contraception","topic":"Reproductive Health and Contraception","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer Canada; Merck Canada; Sigrid Juséliuksen Säätiö; Gedeon Richter; Oregon Health and Science University; Bayer HealthCare; Magee-Womens Research Institute; University of Florida; Suomen Lääketieteen Säätiö; Teva Pharmaceutical Industries; Astellas Pharma; Mylan; GlaxoSmithKline; Fuji Pharma; Pfizer","keywords":"Medicine; Tolerability; Drospirenone; Internal medicine; Adverse effect; Discontinuation; MedDRA; Obstetrics; Pharmacovigilance","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03159088,0.002137793,0.007150269,0.002193896,0.0003451922,0.002426312,0.0008249909,0.001303153,0.002731125],"category_scores_gemma":[0.03372892,0.0008877538,0.01572869,0.002993398,0.0006232,0.001352267,0.000995911,0.0009341033,0.0003318748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006284713,"about_ca_system_score_gemma":0.001236422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004429722,"about_ca_topic_score_gemma":0.001110712,"domain_scores_codex":[0.9797402,0.01224449,0.003537197,0.001952699,0.002240913,0.0002844464],"domain_scores_gemma":[0.9707544,0.01325244,0.01176246,0.001544602,0.002198438,0.0004877591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.2079374,0.0006017415,0.04075152,0.03414865,0.6419085,0.0002252865,0.0002581224,0.002036942,0.004204536,0.0001225764,0.002329737,0.06547497],"study_design_scores_gemma":[0.1042087,0.03449553,0.1411135,0.00413904,0.7019332,0.0008539222,0.0002319805,0.001880707,0.002191778,0.0005118249,0.008206285,0.0002334911],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.524411,0.4414431,0.009141546,0.0008887287,0.0005822502,0.00587474,0.01341714,0.0003796207,0.003861859],"genre_scores_gemma":[0.9325306,0.04499881,0.006391682,0.001014798,0.0006745378,0.005089127,0.008388569,0.0001247683,0.0007870121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03159088,"threshold_uncertainty_score":0.1670705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07147808475339334,"score_gpt":0.4090750583203293,"score_spread":0.337596973566936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}