{"id":"W4306736909","doi":"10.3390/biology11101526","title":"MEKK-3 Acts Cooperatively with NSY-1 in SKN-1-Dependent Manner against Oxidative Stress and Aging in Caenorhabditis elegans","year":2022,"lang":"en","type":"article","venue":"Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Caenorhabditis elegans; Biology; Gene knockdown; Cell biology; MAP kinase kinase kinase; Protein kinase A; Oxidative stress; Kinase; RNA interference; Gene silencing; Oxidative phosphorylation; Signal transduction; ASK1; Biochemistry; Mitogen-activated protein kinase kinase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001235698,0.0005883435,0.000341332,0.0002422382,0.0002424873,0.0001920934,0.0003045965,0.0001950334,0.0007771594],"category_scores_gemma":[0.00008322766,0.0002004253,0.0004865285,0.00009725107,0.0002525332,0.0001732725,0.000309106,0.0005476951,0.0002681743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003709923,"about_ca_system_score_gemma":0.0003771398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294454,"about_ca_topic_score_gemma":0.00356292,"domain_scores_codex":[0.9998868,0.00001059472,0.00001509427,0.00003012287,0.0000285075,0.0000289176],"domain_scores_gemma":[0.9999266,0.000006416031,0.00002307953,0.00000725543,0.000009171128,0.00002740036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001566091,0.00002837903,0.0002045337,0.00007433998,0.000007993581,0.00003432118,0.00001100728,0.00007559092,0.9985801,0.00005016217,0.00004996603,0.0007270344],"study_design_scores_gemma":[0.00005259491,0.0002787396,0.009881184,0.0000122675,0.00003921399,0.0001620717,0.00003343914,0.002192658,0.9849761,0.00005953149,0.002299164,0.00001306044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940925,0.001821774,0.002106544,0.0001261517,0.00005063178,0.00004388356,0.0005180634,0.0001726242,0.001067839],"genre_scores_gemma":[0.9926559,0.001032666,0.003028119,0.00008166499,0.000009708308,0.00008303255,0.0008397611,0.00002819098,0.002240961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294454,"threshold_uncertainty_score":0.002691746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007604052792191772,"score_gpt":0.2256628007565165,"score_spread":0.2180587479643247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}