{"id":"W4306736909","doi":"10.3390/biology11101526","title":"MEKK-3 Acts Cooperatively with NSY-1 in SKN-1-Dependent Manner against Oxidative Stress and Aging in Caenorhabditis elegans","year":2022,"lang":"en","type":"article","venue":"Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Caenorhabditis elegans; Biology; Gene knockdown; Cell biology; MAP kinase kinase kinase; Protein kinase A; Oxidative stress; Kinase; RNA interference; Gene silencing; Oxidative phosphorylation; Signal transduction; ASK1; Biochemistry; Mitogen-activated protein kinase kinase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130519,0.0001993704,0.000228706,0.0001126491,0.0001143299,0.0000181775,0.0002033924,0.0001104349,0.00003240697],"category_scores_gemma":[0.00002830206,0.0001878459,0.00002173965,0.0001144701,0.0001460363,0.000005374324,0.0002964748,0.0002410683,0.000001993994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004833478,"about_ca_system_score_gemma":0.00009593532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003189145,"about_ca_topic_score_gemma":0.0041464,"domain_scores_codex":[0.998547,0.0002678241,0.0002099526,0.0005259091,0.00008647818,0.0003627983],"domain_scores_gemma":[0.9995822,0.00001948179,0.00007639597,0.0002173533,0.00004064841,0.00006392027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002173962,0.0003429394,0.2152309,0.0000384499,0.0001023754,0.0001553731,0.004098,0.009037269,0.7678868,0.0006120377,0.0001904407,0.002088047],"study_design_scores_gemma":[0.00948597,0.005176309,0.1631694,0.0000993536,0.00006352173,0.0002349918,0.0105788,0.001205692,0.7625085,0.0004131566,0.04470174,0.002362621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973803,0.0008296714,0.0005045072,0.0003629659,0.0001139239,0.0002537948,0.0001261308,0.000009299213,0.0004194357],"genre_scores_gemma":[0.9980391,0.0003148638,0.0002848906,0.0005834789,0.0000700957,0.0000717645,0.0002988926,0.00002533107,0.000311638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05206153,"threshold_uncertainty_score":0.7660134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007604052792191772,"score_gpt":0.2256628007565165,"score_spread":0.2180587479643247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}