{"id":"W4306766495","doi":"10.3390/molecules27207025","title":"Tripeptide Leu-Ser-Trp Regulates the Vascular Endothelial Cells Phenotype Switching by Mediating the Vascular Smooth Muscle Cells-Derived Small Extracellular Vesicles Packaging of miR-145","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Tripeptide; Vascular smooth muscle; Cell biology; Endothelial stem cell; Endothelial dysfunction; Extracellular; Chemistry; Vascular endothelial growth factor B; Angiotensin II; Biology; Biochemistry; In vitro; Cancer research; Vascular endothelial growth factor A; Peptide; Receptor; Endocrinology; Vascular endothelial growth factor; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029918,0.0001711286,0.000145262,0.00007436764,0.00009773311,0.0002929039,0.0000932596,0.0001859119,0.0007040469],"category_scores_gemma":[0.00008808829,0.00008392159,0.0001748657,0.00004137776,0.0001607998,0.0001845097,0.0001448437,0.0003080874,0.0002215163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001519543,"about_ca_system_score_gemma":0.00009047163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001410125,"about_ca_topic_score_gemma":0.0001461371,"domain_scores_codex":[0.9999071,0.00002620881,0.000008594196,0.0000215243,0.00001424498,0.00002219966],"domain_scores_gemma":[0.9999564,0.000007257792,0.00001569947,0.000003396271,0.000004135736,0.00001306135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001219558,0.00001403407,0.00008656033,0.00001408512,0.000002318189,0.00003561635,0.000008312158,0.00003072243,0.9990819,0.0001034364,0.0000137188,0.0004873702],"study_design_scores_gemma":[0.00001930762,0.0002316768,0.002565122,0.00000337181,0.0000100719,0.0001175477,0.00002999938,0.001312101,0.994605,0.00004388036,0.001058383,0.000003558445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968251,0.0005472221,0.001882168,0.00003754986,0.00001986876,0.00001261038,0.00006868473,0.00002804047,0.0005788577],"genre_scores_gemma":[0.9983476,0.0001793028,0.0006902499,0.00001880798,0.000003543235,0.00001162564,0.00006220815,0.000007294984,0.000679226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007040469,"threshold_uncertainty_score":0.002355278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007093275116070352,"score_gpt":0.1983043228145188,"score_spread":0.1912110476984484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}