{"id":"W4306772922","doi":"10.1002/jmr.2997","title":"Systematic analysis to identify novel disease indications and plausible potential chemical leads of glutamate ionotropic receptor<scp>NMDA</scp>type subunit 1,<scp>GRIN1</scp>","year":2022,"lang":"en","type":"review","venue":"Journal of Molecular Recognition","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"King Khalid University","keywords":"Ionotropic effect; Schizophrenia (object-oriented programming); NMDA receptor; Disease; Glutamate receptor; Protein subunit; Computational biology; Drug discovery; Genetics; Biology; Chemistry; Pharmacology; Bioinformatics; Gene; Receptor; Medicine; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001220845,0.000776644,0.002472542,0.004100804,0.0002100418,0.0007549547,0.0008047604,0.0005011313,0.003351892],"category_scores_gemma":[0.001812229,0.0002283956,0.002023716,0.004252844,0.0001864299,0.0006035405,0.0005112818,0.0004378537,0.0004461886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007026098,"about_ca_system_score_gemma":0.002446194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001354574,"about_ca_topic_score_gemma":0.004182123,"domain_scores_codex":[0.9996349,0.00009407191,0.00007292561,0.00006759687,0.0001090526,0.00002148352],"domain_scores_gemma":[0.998989,0.0005219841,0.0002133977,0.00004759271,0.0001854204,0.00004257855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.000766243,0.0001517324,0.005350443,0.1921157,0.00952268,0.0008245941,0.0001204425,0.001891061,0.006682816,0.003610151,0.01432294,0.7646412],"study_design_scores_gemma":[0.0006639591,0.002091088,0.03752331,0.06669509,0.0853126,0.006287274,0.0004008651,0.002716362,0.01261042,0.00774794,0.7777613,0.000189705],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00383403,0.9921746,0.001080808,0.0003589636,0.00008959412,0.00009598836,0.001123043,0.00004509726,0.001197809],"genre_scores_gemma":[0.02946929,0.9636576,0.003177876,0.0004799869,0.00009588739,0.0001193064,0.002130966,0.00001619747,0.000852858],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004100804,"threshold_uncertainty_score":0.01121318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02740260224606905,"score_gpt":0.2994095378171673,"score_spread":0.2720069355710982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}