{"id":"W4306803289","doi":"10.1002/cpt.2768","title":"Impact of Drug Exposure on Resistance Selection Following Artemether‐Lumefantrine Treatment for Malaria in Children With and Without <scp>HIV</scp> in Uganda","year":2022,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Malaria Research and Control","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; University of California, San Francisco; National Institute of Child Health and Human Development; National Institute of General Medical Sciences; International Development Research Centre","keywords":"Artemether/lumefantrine; Nevirapine; Lumefantrine; Efavirenz; Lopinavir; Medicine; Malaria; Population; Lopinavir/ritonavir; Ritonavir; Pharmacology; Virology; Internal medicine; Immunology; Viral load; Plasmodium falciparum; Artemisinin; Human immunodeficiency virus (HIV); Antiretroviral therapy; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021455,0.0001920955,0.0006328727,0.0001793587,0.00008781142,0.000007392411,0.0001005407,0.00009206717,0.00003935128],"category_scores_gemma":[0.00004911925,0.0001420017,0.0001904521,0.0002903681,0.000102575,0.00003463114,0.00003088202,0.0005773723,7.861899e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002339862,"about_ca_system_score_gemma":0.0003459857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004311082,"about_ca_topic_score_gemma":0.0001343966,"domain_scores_codex":[0.9979692,0.0005524727,0.0004987164,0.0003767759,0.0002107674,0.0003921462],"domain_scores_gemma":[0.9986466,0.0008637131,0.0001539399,0.0001541622,0.00005278975,0.0001287847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009233732,0.001793406,0.9802233,0.00001407963,0.00178355,0.00001756855,0.0002333858,0.000236382,0.004136311,0.00001922397,0.0003345271,0.001974528],"study_design_scores_gemma":[0.04229106,0.01068954,0.94203,0.00002639216,0.0006810987,0.00001632436,0.00009970909,0.001826226,0.0007734743,0.00007546751,0.001414609,0.00007607147],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945033,0.0007005947,0.00005859104,0.002555747,0.0001060907,0.001961195,0.00002772657,0.00001913234,0.00006762464],"genre_scores_gemma":[0.9966593,0.0002768839,0.0002250034,0.001470795,0.0001287479,0.000355464,0.00002430828,0.00003100267,0.0008284643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03819328,"threshold_uncertainty_score":0.5790661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429054703106308,"score_gpt":0.4118038061710506,"score_spread":0.3688983358604198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}