{"id":"W4306803289","doi":"10.1002/cpt.2768","title":"Impact of Drug Exposure on Resistance Selection Following Artemether‐Lumefantrine Treatment for Malaria in Children With and Without <scp>HIV</scp> in Uganda","year":2022,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Malaria Research and Control","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; University of California, San Francisco; National Institute of Child Health and Human Development; National Institute of General Medical Sciences; International Development Research Centre","keywords":"Artemether/lumefantrine; Nevirapine; Lumefantrine; Efavirenz; Lopinavir; Medicine; Malaria; Population; Lopinavir/ritonavir; Ritonavir; Pharmacology; Virology; Internal medicine; Immunology; Viral load; Plasmodium falciparum; Artemisinin; Human immunodeficiency virus (HIV); Antiretroviral therapy; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001752908,0.0003959406,0.0007398669,0.0002426482,0.0002730911,0.0007180664,0.0004362701,0.0005516494,0.001123139],"category_scores_gemma":[0.005005342,0.0004731238,0.0008315856,0.0002207492,0.0004364286,0.0004441485,0.0006606458,0.0006549756,0.000102544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00118309,"about_ca_system_score_gemma":0.0008507448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01674428,"about_ca_topic_score_gemma":0.009474385,"domain_scores_codex":[0.9991933,0.000474714,0.00002887564,0.0001149755,0.00004694329,0.0001413519],"domain_scores_gemma":[0.9972289,0.002002089,0.0004731333,0.00009703403,0.00007570225,0.000123132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002376125,0.0002630835,0.627123,0.0000679095,0.0005836373,0.001176209,0.000546688,0.3549295,0.002368669,0.0007617792,0.0002515081,0.009551882],"study_design_scores_gemma":[0.0001576916,0.002210251,0.2364494,0.00004650098,0.0003579894,0.001024251,0.0005867879,0.7557219,0.002031863,0.0007997346,0.0005547038,0.00005893812],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992887,0.00005492961,0.0004794568,0.00002067858,6.460942e-7,0.000006429799,0.00004707303,0.000004647821,0.00009743087],"genre_scores_gemma":[0.999458,0.00003667526,0.0003046011,0.000006527192,5.51663e-7,0.000009111018,0.00006114798,0.00000186771,0.0001214104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01674428,"threshold_uncertainty_score":0.03329366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429054703106308,"score_gpt":0.4118038061710506,"score_spread":0.3688983358604198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}