{"id":"W4306822067","doi":"10.1021/jacs.2c06695","title":"Length-Controlled Nanofiber Micelleplexes as Efficient Nucleic Acid Delivery Vehicles","year":2022,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; University of Victoria; Canada Research Chairs; Wellcome Trust; Wellcome","keywords":"Nanofiber; Lipofectamine; Nucleic acid; Transfection; Chemistry; Nanotechnology; Biophysics; Gene delivery; Dynamic light scattering; Nanorod; Nanoparticle; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003613988,0.000411311,0.0001737455,0.0002208094,0.00009104647,0.0003258276,0.0001688396,0.000387453,0.0008120865],"category_scores_gemma":[0.0003768216,0.0001230386,0.0001448023,0.0001062208,0.0002245902,0.0006512583,0.0001682645,0.0003032563,0.0002897567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003203013,"about_ca_system_score_gemma":0.0001462984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002073937,"about_ca_topic_score_gemma":0.0003302494,"domain_scores_codex":[0.9998752,0.00002153499,0.00001478923,0.00004034354,0.00003332613,0.00001470825],"domain_scores_gemma":[0.9997812,0.00005420744,0.00009641446,0.00001306885,0.00003729529,0.00001785547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001485403,0.00001206555,0.00005638426,0.00002255092,0.000002228697,0.00001278771,0.00001103293,0.0002612832,0.9983991,0.0001138442,0.00002571383,0.001068148],"study_design_scores_gemma":[0.00000938748,0.0001428363,0.0004481473,0.000004461322,0.00000506304,0.00005119887,0.000006019635,0.002106676,0.9956447,0.00005867041,0.001515829,0.000006970197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721146,0.002782011,0.02241082,0.0001344475,0.00005050386,0.000135723,0.000239425,0.0002809501,0.001851573],"genre_scores_gemma":[0.9631104,0.001732343,0.03083821,0.000101635,0.0000297144,0.0001281599,0.0002758406,0.00007268676,0.003710963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008120865,"threshold_uncertainty_score":0.00271666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005647992131201419,"score_gpt":0.2242993315418489,"score_spread":0.2186513394106475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}