{"id":"W4306822067","doi":"10.1021/jacs.2c06695","title":"Length-Controlled Nanofiber Micelleplexes as Efficient Nucleic Acid Delivery Vehicles","year":2022,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; University of Victoria; Canada Research Chairs; Wellcome Trust; Wellcome","keywords":"Nanofiber; Lipofectamine; Nucleic acid; Transfection; Chemistry; Nanotechnology; Biophysics; Gene delivery; Dynamic light scattering; Nanorod; Nanoparticle; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003095498,0.0001527629,0.0003335231,0.00001566177,0.0002041184,0.00002263004,0.0006685717,0.00004384565,0.00007166853],"category_scores_gemma":[0.00006183026,0.0001054235,0.0009998055,0.0001594154,0.0002501529,0.00000342518,0.0004542669,0.0003261977,0.000005993635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008167014,"about_ca_system_score_gemma":0.0001415405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002341716,"about_ca_topic_score_gemma":3.917414e-7,"domain_scores_codex":[0.998708,0.0001195485,0.000365924,0.0001931433,0.0003716315,0.0002418137],"domain_scores_gemma":[0.9989034,0.00003660485,0.0005902316,0.0002652284,0.0001228002,0.00008175681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007324037,0.0001338639,0.0003151237,0.000002967185,0.000256295,0.000002579405,0.0001576893,0.000412121,0.9735488,0.00000203453,0.0234763,0.0009598702],"study_design_scores_gemma":[0.001630969,0.0004763885,0.0002511832,0.000009419407,0.00009288784,0.0001368917,0.001565271,0.0002623457,0.9818953,0.00003393255,0.01346888,0.0001765614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997337,0.001125915,0.0000216528,0.001017954,0.0002302961,0.00009445776,0.00001001005,0.000004618544,0.0001580712],"genre_scores_gemma":[0.9955633,0.0002428382,0.0003858906,0.003126438,0.0003022379,0.000008909864,0.000003160555,0.00001888483,0.0003483821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01000742,"threshold_uncertainty_score":0.4299046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005647992131201419,"score_gpt":0.2242993315418489,"score_spread":0.2186513394106475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}