{"id":"W4306822626","doi":"10.21203/rs.3.rs-2167397/v1","title":"Hereditary acute myeloid leukemia associated with C-terminal CEBPA germline variants","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"CEBPA; Germline; Myeloid leukemia; Germline mutation; Leukemia; Myeloid; Acute leukemia; Penetrance; Cancer research; Biology; Somatic cell; Medicine; Genetics; Mutation; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000118794,0.0003351973,0.0002081437,0.000555423,0.0002923353,0.0002789911,0.0001251256,0.0003733681,0.004368166],"category_scores_gemma":[0.001122958,0.00006851911,0.0001655544,0.0005183951,0.0002951391,0.0001866241,0.0002645459,0.0002955685,0.0006388598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000180625,"about_ca_system_score_gemma":0.0002035178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008419725,"about_ca_topic_score_gemma":0.0005475375,"domain_scores_codex":[0.9998401,0.00003317434,0.00001653145,0.00003015642,0.00004033644,0.00003962633],"domain_scores_gemma":[0.9996356,0.0001534281,0.00009850943,0.00002678084,0.000030552,0.00005509456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.000466295,0.000100836,0.2677543,0.0002554179,0.000105267,0.6350221,0.0006228313,0.0005751249,0.04917258,0.003803907,0.003494175,0.03862717],"study_design_scores_gemma":[0.00003903388,0.0001375626,0.1416361,0.00007810018,0.00007169459,0.8307953,0.0003519456,0.000675729,0.01198851,0.00188187,0.0123244,0.00001979041],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858902,0.001638721,0.001858956,0.0004842282,0.00008328656,0.00002666773,0.0004658534,0.0001102059,0.009441919],"genre_scores_gemma":[0.9974343,0.0004618184,0.0004615679,0.00006291638,0.00007559851,0.000004350024,0.0001588355,0.0000104819,0.001330023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004368166,"threshold_uncertainty_score":0.01461291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05066912647016752,"score_gpt":0.3806944854331402,"score_spread":0.3300253589629727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}