{"id":"W4306832729","doi":"10.1161/circulationaha.122.060210","title":"Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation","funders":"British Heart Foundation","keywords":"Medicine; Internal medicine; Endocrinology; Phosphodiesterase; Exon; Mutation; Mutant; Biology; Genetics; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527108,0.0001451802,0.0001397512,0.00004666063,0.0003752183,0.00002895265,0.00009263468,0.00008405262,0.0001482778],"category_scores_gemma":[0.00004846581,0.0001512283,0.0001061625,0.0001324605,0.00002213972,0.000009342171,0.0001223816,0.0001173104,0.0000176676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006314991,"about_ca_system_score_gemma":0.00006345963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009824913,"about_ca_topic_score_gemma":0.000006135591,"domain_scores_codex":[0.9988696,0.0001403839,0.0001967828,0.0003910213,0.0002342618,0.0001679525],"domain_scores_gemma":[0.9993557,0.00001329779,0.0001066257,0.0003837982,0.00007322481,0.00006732051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001017843,0.00005312201,0.008925977,0.00000427968,0.0000425723,0.000006257522,0.000105494,0.001743546,0.9858351,0.00003374318,0.0004675287,0.002680551],"study_design_scores_gemma":[0.001336718,0.0001817741,0.4425555,0.00001329896,0.00005691726,0.00001723384,0.0003818978,0.004932562,0.5185894,0.0003145004,0.03109763,0.0005226046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970397,0.0002224244,0.0007602316,0.0001280443,0.0009929634,0.0004168689,0.00005661687,0.00004328378,0.0003398945],"genre_scores_gemma":[0.9977317,0.000009883754,0.00009988232,0.0003913482,0.0002587204,0.0001256712,0.001234511,0.00002690639,0.000121337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4672458,"threshold_uncertainty_score":0.6166912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577737006954832,"score_gpt":0.2164644026596017,"score_spread":0.2006870325900533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}