{"id":"W4306842654","doi":"10.26685/urncst.373","title":"The Use of Mannose-Grafted and Lipopeptide-Conjugated PE Liposomes in the Delivery of Docetaxel for the Treatment of Glioblastoma Multiforme: A Research Protocol","year":2022,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Liposome; Drug delivery; Blood–brain barrier; Docetaxel; Phosphatidylethanolamine; Targeted drug delivery; Pharmacology; Calcein; Endocytosis; Chemistry; Drug; Medicine; Cancer; Cell; Biochemistry; Phosphatidylcholine; Internal medicine; Phospholipid; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002791399,0.0004830092,0.0002385442,0.0002483717,0.0002782558,0.0002260631,0.0003201136,0.0003929813,0.0008152312],"category_scores_gemma":[0.0001332776,0.0001626497,0.000351914,0.0002356689,0.0001702282,0.0003152418,0.0002265741,0.0003669032,0.0002942356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003941354,"about_ca_system_score_gemma":0.0004382448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007010848,"about_ca_topic_score_gemma":0.0007518145,"domain_scores_codex":[0.9998748,0.00001258142,0.00001830563,0.00003269238,0.00003817245,0.00002333257],"domain_scores_gemma":[0.9999461,0.000004947583,0.00001415333,0.000008333212,0.0000175994,0.000008749103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001123033,0.00007260049,0.00006458625,0.000128452,0.000005587318,0.00006898368,0.00002554456,0.0002255191,0.9958864,0.0003129685,0.00009999565,0.002997093],"study_design_scores_gemma":[0.0000421296,0.000827834,0.0004527739,0.00001015161,0.00002644849,0.0001526726,0.00001144722,0.0005595306,0.9928204,0.00005004192,0.005032659,0.0000138606],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9505144,0.005725595,0.03198506,0.0003009226,0.0001203857,0.003809372,0.001147907,0.0001524446,0.00624396],"genre_scores_gemma":[0.9427966,0.006947109,0.03607018,0.0001537825,0.00002486645,0.002521691,0.001615749,0.00003736676,0.009832648],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.0008152312,"threshold_uncertainty_score":0.002859652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1150249260312824,"score_gpt":0.4217101643140059,"score_spread":0.3066852382827236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}