{"id":"W4306847680","doi":"10.1101/2022.10.18.512679","title":"The epigenetic modifier DOT1L regulates gene regulatory networks necessary for cardiac patterning and cardiomyocyte cell cycle withdrawal","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada)","funders":"School of Medicine, University of California, San Diego; University of California, San Diego; Francis Crick Institute","keywords":"Biology; Cell biology; Gene silencing; Epigenetics; Gene; Regulation of gene expression; Embryonic stem cell; Cell cycle; Histone; Gene expression; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009089943,0.0002519993,0.0002035102,0.0001836415,0.0001437034,0.0002474666,0.0001536123,0.0002309681,0.001524555],"category_scores_gemma":[0.00007461049,0.0001758349,0.0001461225,0.00007855631,0.0002487655,0.0001284182,0.0003768404,0.0003716376,0.0006012585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003348907,"about_ca_system_score_gemma":0.0001393126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003879967,"about_ca_topic_score_gemma":0.0008127193,"domain_scores_codex":[0.9999017,0.000008207612,0.00000595301,0.0000352745,0.00002606633,0.00002281104],"domain_scores_gemma":[0.9999068,0.00001156459,0.00003523949,0.00001147757,0.000008154584,0.00002672816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002321579,0.000003258556,0.0001525247,0.000007703448,8.732427e-7,0.00002378979,0.000003637859,0.00002627635,0.9993969,0.00004402769,0.00001352361,0.0003043383],"study_design_scores_gemma":[0.000009209181,0.00003547161,0.008475,0.00000298106,0.000004777155,0.0001220992,0.00001604317,0.001272969,0.9883804,0.00004060519,0.001637498,0.000002888058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928733,0.0007662015,0.00423102,0.00009517893,0.00002312976,0.00001201335,0.0003980014,0.0001290941,0.001472053],"genre_scores_gemma":[0.9924936,0.000251208,0.001753768,0.00005279907,0.000006969621,0.00001810417,0.000737472,0.00006513215,0.004620881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001524555,"threshold_uncertainty_score":0.005100191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007385062214667235,"score_gpt":0.2219805635664083,"score_spread":0.214595501351741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}