{"id":"W4306867618","doi":"10.3324/haematol.2022.280678","title":"Three-year results from phase I of ZUMA-4: KTE-X19 in pediatric relapsed/refractory acute lymphoblastic leukemia","year":2022,"lang":"en","type":"article","venue":"Haematologica","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Gilead Sciences","keywords":"Medicine; Refractory (planetary science); Gastroenterology; Internal medicine; Cytokine release syndrome; Adverse effect; Anemia; Incidence (geometry); Surgery; Chimeric antigen receptor; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002476768,0.0006795465,0.001157379,0.000342948,0.0004413377,0.000692034,0.0003650112,0.0004852203,0.001005413],"category_scores_gemma":[0.0009129312,0.000165372,0.0008578578,0.0002403281,0.0003017759,0.00041525,0.0003353599,0.001349157,0.0003139443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005892012,"about_ca_system_score_gemma":0.0005515103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008964498,"about_ca_topic_score_gemma":0.001693693,"domain_scores_codex":[0.9995401,0.0001843513,0.00003555109,0.0000448709,0.00007273298,0.0001225057],"domain_scores_gemma":[0.9990875,0.0002174931,0.0002570341,0.00009230429,0.00009719717,0.0002485973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1334595,0.0427857,0.1043348,0.001197001,0.002654887,0.001396321,0.001108167,0.01500555,0.2027356,0.0005133575,0.009308071,0.485501],"study_design_scores_gemma":[0.03424402,0.5867185,0.2622934,0.00014382,0.002852478,0.00295885,0.0004272079,0.005804102,0.0803152,0.0005183661,0.02364135,0.00008269922],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920381,0.00405731,0.00113779,0.0001646204,0.00002649,0.000303317,0.000922916,0.0000746844,0.001274774],"genre_scores_gemma":[0.9893444,0.002420262,0.001462694,0.0003760203,0.00005035262,0.0003617161,0.004248195,0.00004039604,0.001695972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002476768,"threshold_uncertainty_score":0.01309854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03940613311196696,"score_gpt":0.3146591669903849,"score_spread":0.2752530338784179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}