{"id":"W4306867618","doi":"10.3324/haematol.2022.280678","title":"Three-year results from phase I of ZUMA-4: KTE-X19 in pediatric relapsed/refractory acute lymphoblastic leukemia","year":2022,"lang":"en","type":"article","venue":"Haematologica","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Gilead Sciences","keywords":"Medicine; Refractory (planetary science); Gastroenterology; Internal medicine; Cytokine release syndrome; Adverse effect; Anemia; Incidence (geometry); Surgery; Chimeric antigen receptor; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006484463,0.0002536011,0.000839422,0.0004528568,0.000122638,0.0000126466,0.0004166449,0.0001755528,0.007626355],"category_scores_gemma":[0.0005389819,0.0002211377,0.0001997876,0.0009196349,0.0001427709,0.00006498944,0.0003715444,0.0007877015,0.0001387781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006356744,"about_ca_system_score_gemma":0.0006162872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005412946,"about_ca_topic_score_gemma":0.00007798782,"domain_scores_codex":[0.9969127,0.0002268652,0.0008050349,0.0006422368,0.0008845541,0.0005285672],"domain_scores_gemma":[0.9977136,0.0008756176,0.0002884544,0.0008438057,0.00009003549,0.000188456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.2054958,0.01753464,0.2433925,0.001234029,0.001858731,0.04807472,0.01033299,0.0006518695,0.2791505,0.00308066,0.1472279,0.04196575],"study_design_scores_gemma":[0.362122,0.04403969,0.3635267,0.0007169862,0.002959697,0.004509399,0.006230586,0.01291995,0.05103917,0.0164147,0.1310405,0.004480709],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991781,0.0007700397,0.00003637763,0.0003517055,0.0002331696,0.0006912537,0.0003724305,0.0001012944,0.005662703],"genre_scores_gemma":[0.9971703,0.0005137405,0.0004691092,0.0001472952,0.0001324986,0.0001125479,0.00026983,0.00004438574,0.001140301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2281113,"threshold_uncertainty_score":0.9932808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03940613311196696,"score_gpt":0.3146591669903849,"score_spread":0.2752530338784179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}