{"id":"W4306882574","doi":"10.1085/jgp.202213272","title":"The road to the brain in Timothy syndrome is paved with enhanced CaV1.2 activation gating","year":2022,"lang":"en","type":"letter","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gating; Neuroscience; Sensory gating; Nervous system; Chemistry; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000763134,0.0007291948,0.000960061,0.0004293877,0.001292023,0.001106257,0.0008898201,0.02070536,0.002984306],"category_scores_gemma":[0.006340997,0.0003501626,0.0007007659,0.0003181569,0.001607005,0.001736298,0.0004892973,0.01406699,0.002243343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001530231,"about_ca_system_score_gemma":0.0008603992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002263307,"about_ca_topic_score_gemma":0.002700705,"domain_scores_codex":[0.9994926,0.0001302082,0.00006160772,0.00008791542,0.00012662,0.0001009915],"domain_scores_gemma":[0.9983149,0.001083333,0.00009354261,0.00008426365,0.0002197697,0.0002041799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006599511,0.0001521402,0.004418181,0.0001486833,0.00006405179,0.1646116,0.0003342796,0.0003298252,0.004062138,0.008706501,0.7833958,0.03311693],"study_design_scores_gemma":[0.0008284976,0.0006999022,0.01388628,0.0005220052,0.000205068,0.2356189,0.000839364,0.006124691,0.005123607,0.05260541,0.6832601,0.0002862006],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.008516191,0.001839272,0.0005286507,0.9576605,0.02488829,0.00002607095,0.00013174,0.0001334595,0.006275915],"genre_scores_gemma":[0.1081992,0.004576194,0.001706594,0.7533965,0.1114624,0.00009688295,0.0001414109,0.0001161423,0.02030466],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02070536,"threshold_uncertainty_score":0.01110268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009856140516757926,"score_gpt":0.2364580435821988,"score_spread":0.2266019030654409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}