{"id":"W4306895319","doi":"10.1126/science.abn9884","title":"Structure of the hepatitis C virus E1E2 glycoprotein complex","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Hepatitis C virus research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Infection and Immunity; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Bill and Melinda Gates Foundation; National Institutes of Health; National Science Foundation","keywords":"Virology; Glycoprotein; Epitope; Neutralizing antibody; Hepatocellular carcinoma; Hepatitis C virus; Antibody; Viral entry; Rational design; Viral envelope; CD81; Virus; Biology; Capsid; Chemistry; Immunology; Viral replication; Cancer research; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008896794,0.0004068654,0.00028154,0.0001861168,0.0008598697,0.0005013272,0.0006455046,0.0005304451,0.002955305],"category_scores_gemma":[0.0002059072,0.0002699914,0.0001892417,0.0002798484,0.000369099,0.000620732,0.0003117619,0.001063698,0.000480224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007472567,"about_ca_system_score_gemma":0.0003596931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005302398,"about_ca_topic_score_gemma":0.003841884,"domain_scores_codex":[0.9999367,0.000007436735,0.000002523409,0.00001433072,0.00002520599,0.00001382575],"domain_scores_gemma":[0.9999352,0.00001337438,0.00001257296,0.000004748767,0.00001760745,0.00001653286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001044315,0.0003046673,0.01103008,0.0008390932,0.0001887426,0.003183635,0.000809179,0.02093303,0.9226424,0.009675868,0.01444143,0.01490762],"study_design_scores_gemma":[0.0003674645,0.001448674,0.1767315,0.0003999272,0.0002717254,0.007975891,0.002629578,0.3490729,0.3379622,0.01049578,0.1122009,0.0004433902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656699,0.009782004,0.007207754,0.001784442,0.0001321007,0.00003866668,0.001535753,0.0002840229,0.01356535],"genre_scores_gemma":[0.9834263,0.004436716,0.004327767,0.0005101561,0.00003906356,0.0000295061,0.00373173,0.00006611862,0.003432696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005302398,"threshold_uncertainty_score":0.01054305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03331120535524702,"score_gpt":0.3253995122775581,"score_spread":0.2920883069223111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}