{"id":"W4306895319","doi":"10.1126/science.abn9884","title":"Structure of the hepatitis C virus E1E2 glycoprotein complex","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Hepatitis C virus research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Infection and Immunity; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Bill and Melinda Gates Foundation; National Institutes of Health; National Science Foundation","keywords":"Virology; Glycoprotein; Epitope; Neutralizing antibody; Hepatocellular carcinoma; Hepatitis C virus; Antibody; Viral entry; Rational design; Viral envelope; CD81; Virus; Biology; Capsid; Chemistry; Immunology; Viral replication; Cancer research; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003662082,0.00005757563,0.0001184982,0.0001054024,0.0004840936,0.00001529666,0.0006160442,0.00001342072,0.003503361],"category_scores_gemma":[0.0003314258,0.00003981463,0.0000408205,0.001439537,0.0008617676,0.00006584729,0.0005798553,0.0002681981,0.00001325813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001727868,"about_ca_system_score_gemma":0.0006404399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002097208,"about_ca_topic_score_gemma":0.0005447507,"domain_scores_codex":[0.9978229,0.00007193377,0.0001396018,0.0002166748,0.001485546,0.0002633726],"domain_scores_gemma":[0.9992194,0.00002354258,0.00005337078,0.0004924501,0.0001196389,0.00009160818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001727206,0.00002711887,0.09016626,0.00001558058,0.000003201871,0.00001018168,0.0002823787,0.00002735961,0.8986797,0.0005352481,0.0007452058,0.009490503],"study_design_scores_gemma":[0.0004292052,0.0002868632,0.6903542,0.0000185399,0.0000067136,0.00004292226,0.0000769514,0.001900576,0.2638176,0.0008570742,0.0421201,0.00008925593],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994285,0.00005054978,0.00001653923,0.001106295,0.0001666025,0.0004004778,0.0001191379,0.00001506366,0.003840343],"genre_scores_gemma":[0.9984038,0.000009647752,0.0005705655,0.0004704984,0.00002599947,0.00001225992,0.000002379242,0.000006330897,0.0004985035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6348621,"threshold_uncertainty_score":0.9974076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03331120535524702,"score_gpt":0.3253995122775581,"score_spread":0.2920883069223111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}