{"id":"W4306911627","doi":"10.1158/2159-8290.cd-22-0561","title":"An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas","year":2022,"lang":"en","type":"editorial","venue":"Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; BC Cancer Foundation; National Institute of Allergy and Infectious Diseases; Gilead Sciences; Knut och Alice Wallenbergs Stiftelse; National Cancer Institute; Center for Innovative Medicine; National Institutes of Health; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Radiumhemmets Forskningsfonder; Canadian Institutes of Health Research; Cancerfonden; Pershing Square Sohn Cancer Research Alliance; Leukemia and Lymphoma Society; National Institute of Mental Health; Vetenskapsrådet; WorldQuant Foundation; American Society of Hematology; Memorial Sloan-Kettering Cancer Center; Vallee Foundation; Michael Smith Health Research BC; AstraZeneca; Else Kröner-Fresenius-Stiftung","keywords":"Transformation (genetics); Cancer research; Computational biology; Immunology; Medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002409674,0.0004134825,0.0008495844,0.0001108244,0.0001866949,0.0001214505,0.0003187697,0.0003226681,0.0003136284],"category_scores_gemma":[0.00002694964,0.0002625876,0.0005097002,0.0002392873,0.0001462955,0.0003918883,0.00004016702,0.0003556311,0.000005506402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006801583,"about_ca_system_score_gemma":0.001448782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002691824,"about_ca_topic_score_gemma":0.000113664,"domain_scores_codex":[0.9974318,0.0001176662,0.0006204076,0.0004248157,0.001070878,0.0003344653],"domain_scores_gemma":[0.9984496,0.0002532427,0.0003772768,0.000710878,0.0001258159,0.00008324096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005137947,0.008831855,0.007064971,0.002638268,0.001684338,0.0001344594,0.006478721,0.0001366577,0.0009549772,0.0002683032,0.8733047,0.09336482],"study_design_scores_gemma":[0.0162416,0.002524566,0.02817194,0.0005157539,0.002307645,0.00000752373,0.0004600382,0.00002496408,0.002119522,0.00004234481,0.9471368,0.0004473222],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"empirical","genre_scores_codex":[0.4023988,0.02471588,0.00001234145,0.000397159,0.5623413,0.003731978,0.001970009,0.0001595201,0.004273029],"genre_scores_gemma":[0.675948,0.01180757,0.00006648701,0.0001122812,0.2972508,0.006998042,0.004814533,0.000161535,0.002840677],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2735493,"threshold_uncertainty_score":0.9999827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068195851599362,"score_gpt":0.2841240747523021,"score_spread":0.2734421162363085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}