{"id":"W4306911627","doi":"10.1158/2159-8290.cd-22-0561","title":"An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas","year":2022,"lang":"en","type":"editorial","venue":"Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; BC Cancer Foundation; National Institute of Allergy and Infectious Diseases; Gilead Sciences; Knut och Alice Wallenbergs Stiftelse; National Cancer Institute; Center for Innovative Medicine; National Institutes of Health; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Radiumhemmets Forskningsfonder; Canadian Institutes of Health Research; Cancerfonden; Pershing Square Sohn Cancer Research Alliance; Leukemia and Lymphoma Society; National Institute of Mental Health; Vetenskapsrådet; WorldQuant Foundation; American Society of Hematology; Memorial Sloan-Kettering Cancer Center; Vallee Foundation; Michael Smith Health Research BC; AstraZeneca; Else Kröner-Fresenius-Stiftung","keywords":"Transformation (genetics); Cancer research; Computational biology; Immunology; Medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009512592,0.0001646008,0.0001521092,0.0003642029,0.00008517885,0.000250991,0.00009709299,0.000161906,0.001379741],"category_scores_gemma":[0.0001589052,0.00008200468,0.00007459299,0.0001690843,0.0001354249,0.0001830961,0.0001972907,0.0002002839,0.0004571904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008936143,"about_ca_system_score_gemma":0.0000731929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001569176,"about_ca_topic_score_gemma":0.0001831719,"domain_scores_codex":[0.9999282,0.00001269195,0.000006836024,0.00002090667,0.00001415773,0.00001714925],"domain_scores_gemma":[0.9998612,0.00001115506,0.00005609193,0.00001202419,0.00001659869,0.00004284646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006127508,0.00005901295,0.1228663,0.00006410525,0.00001133674,0.001110292,0.0001283185,0.0000788818,0.8634817,0.0002134113,0.0001322781,0.01124163],"study_design_scores_gemma":[0.00002109452,0.0008228741,0.9144905,0.00002425354,0.00003332259,0.01247831,0.0002599016,0.0004955262,0.0671017,0.0002445297,0.004019529,0.000008422025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.99713,0.001161585,0.0006366801,0.0000162706,0.000004908578,0.0000116184,0.0001370885,0.00003452946,0.0008673717],"genre_scores_gemma":[0.9984729,0.0003812211,0.000386758,0.00003338798,0.00001254617,0.000009023756,0.0002759039,0.000007931634,0.0004204162],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.001379741,"threshold_uncertainty_score":0.004615664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068195851599362,"score_gpt":0.2841240747523021,"score_spread":0.2734421162363085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}