{"id":"W4306912051","doi":"10.1111/dme.14984","title":"Loss of tetraspanin‐7 expression reduces pancreatic β‐cell exocytosis Ca<sup>2+</sup> sensitivity but has limited effect on systemic metabolism","year":2022,"lang":"en","type":"article","venue":"Diabetic Medicine","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Novo Nordisk Fonden; Fonds De La Recherche Scientifique - FNRS; Diabetes UK; Juvenile Diabetes Research Foundation United States of America","keywords":"Exocytosis; Internal medicine; Endocrinology; Pancreatic islets; Insulin; Islet; Gene knockdown; Cell culture; Glucagon; Secretion; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001803672,0.0005302831,0.001955151,0.0005892827,0.0003266298,0.00001506567,0.0001773603,0.0001556505,0.001729795],"category_scores_gemma":[0.002092009,0.0003882427,0.0002502054,0.0007965838,0.0004377797,0.00008494033,0.0001309655,0.000632833,0.00007723526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002029927,"about_ca_system_score_gemma":0.0001799985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002311082,"about_ca_topic_score_gemma":2.727689e-7,"domain_scores_codex":[0.9951534,0.001221106,0.0008869838,0.0007140496,0.001403225,0.0006212094],"domain_scores_gemma":[0.9954282,0.002605402,0.000405413,0.0009040277,0.0001854226,0.0004715262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0014212,0.0008076951,0.01538443,0.001920303,0.0003656354,0.0003042644,0.002910622,0.001170591,0.9641541,0.00004604309,0.00986048,0.001654633],"study_design_scores_gemma":[0.01805038,0.008537652,0.01228474,0.004491088,0.003631272,0.0004216372,0.00623231,0.01235805,0.9307407,0.00005775575,0.002398273,0.0007961908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896932,0.003499858,0.00006101841,0.001089593,0.0005920267,0.001182824,0.00007932518,0.0001698787,0.00363223],"genre_scores_gemma":[0.9961078,0.0001098057,0.0001029907,0.001131904,0.0004778194,0.0002600522,0.0002379773,0.00007430976,0.001497299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03341345,"threshold_uncertainty_score":0.9998569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782878611368028,"score_gpt":0.2397144764141914,"score_spread":0.2218856903005111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}