{"id":"W4306913474","doi":"10.1001/jamaoncol.2022.5068","title":"Methodologic Concerns in Secondary Analysis of KEYNOTE-048","year":2022,"lang":"en","type":"letter","venue":"JAMA Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Otorhinolaryngology; Family medicine; Neurology; MEDLINE; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4697352,0.002954059,0.004269365,0.004899767,0.002963646,0.007935234,0.005305487,0.004313498,0.02100764],"category_scores_gemma":[0.7762467,0.001770404,0.006806001,0.006895542,0.005687239,0.005908559,0.00340532,0.00598173,0.004543771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005168408,"about_ca_system_score_gemma":0.006536094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003265478,"about_ca_topic_score_gemma":0.005695709,"domain_scores_codex":[0.2837532,0.6031121,0.05094732,0.0238175,0.03501846,0.003351447],"domain_scores_gemma":[0.2945324,0.6045353,0.02216356,0.0587704,0.01849246,0.001505931],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01766789,0.002435709,0.1305953,0.0388572,0.0295931,0.004952052,0.01812581,0.006623462,0.001700065,0.1644046,0.3553839,0.229661],"study_design_scores_gemma":[0.01166987,0.004226129,0.06689849,0.02544879,0.01357099,0.003533057,0.006536324,0.05327607,0.008132203,0.3069118,0.4990803,0.0007159484],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"commentary","genre_scores_codex":[0.05869435,0.01664668,0.5915332,0.05287222,0.04703263,0.1221221,0.02458472,0.004115487,0.08239867],"genre_scores_gemma":[0.5570795,0.001294892,0.1801404,0.03723021,0.003902219,0.2039608,0.002601603,0.001506598,0.01228379],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5302647,"threshold_uncertainty_score":0.6539109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07565656600452525,"score_gpt":0.4437276431512903,"score_spread":0.368071077146765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}