{"id":"W4306930552","doi":"10.3389/fimmu.2022.1029006","title":"Low perforin expression in CD8+ T lymphocytes during the acute phase of severe SARS-CoV-2 infection predicts long COVID","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Long-Term Effects of COVID-19","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Centre Hospitalier Universitaire de Nîmes; Agence Nationale de la Recherche","keywords":"Perforin; Immunology; Granzyme; Cytotoxic T cell; Medicine; Granulysin; CD8; Granzyme A; Granzyme B; Immune system; Virology; Degranulation; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657299,0.0003264414,0.0003041101,0.0003322081,0.0002452324,0.0004259453,0.0001069734,0.000410208,0.001361881],"category_scores_gemma":[0.0008657549,0.0002092732,0.0001521943,0.0001926912,0.0002749604,0.00025837,0.0002649826,0.0004146186,0.0003153861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279501,"about_ca_system_score_gemma":0.00008772407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003528875,"about_ca_topic_score_gemma":0.0003709104,"domain_scores_codex":[0.9998388,0.00003211367,0.00002184972,0.00004942164,0.00001890898,0.00003884924],"domain_scores_gemma":[0.9995863,0.00008446049,0.0001486002,0.00002551562,0.00003622934,0.0001189143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001259754,0.00008726051,0.9716177,0.00002365466,0.00002112953,0.0006123274,0.0002018764,0.00007211818,0.02351372,0.00001726385,0.00006702399,0.002506118],"study_design_scores_gemma":[0.00002159246,0.0006161537,0.9961988,0.000005001704,0.00001549959,0.001526057,0.0001621218,0.000168309,0.001134562,0.00002681928,0.0001210812,0.000003900922],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999785,0.00005908611,0.00003341946,0.000006556858,0.000001767284,0.000003034804,0.0000230882,0.000001590702,0.00008637305],"genre_scores_gemma":[0.9997749,0.00002151503,0.00002789815,0.000008744278,0.000006638119,0.00000469175,0.00006614538,7.497763e-7,0.00008870904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361881,"threshold_uncertainty_score":0.004555941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00973105572736432,"score_gpt":0.2838888597308861,"score_spread":0.2741578040035217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}