{"id":"W4306940023","doi":"10.1182/blood.2022016362","title":"Venetoclax and idasanutlin in relapsed/refractory AML: a nonrandomized, open-label phase 1b trial","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"Foundation Medicine; Genentech","keywords":"Venetoclax; Medicine; Internal medicine; Gastroenterology; Neutropenia; Febrile neutropenia; Oncology; Leukemia; Chemotherapy; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001655864,0.0001863807,0.0006314965,0.0002711061,0.0001725786,0.00005223827,0.0003602421,0.00009671515,0.0005522656],"category_scores_gemma":[0.0005530044,0.0001762673,0.00005546326,0.0004318713,0.00008946281,0.00009202131,0.0007197538,0.0009888381,0.00003090466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000384083,"about_ca_system_score_gemma":0.001173955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003299094,"about_ca_topic_score_gemma":0.00002914141,"domain_scores_codex":[0.9976927,0.000435315,0.0004494885,0.0004800247,0.0005092821,0.0004331986],"domain_scores_gemma":[0.9987811,0.000373486,0.0001053233,0.0004662803,0.00004285785,0.0002308804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8875256,0.03752602,0.0007872459,0.0001337254,0.0004818826,0.00397087,0.001396557,0.00000710799,0.04090544,0.0001883222,0.012641,0.01443619],"study_design_scores_gemma":[0.9674566,0.006430566,0.00008093751,0.00003716773,0.0001646043,0.0002084341,0.0002155859,0.000577618,0.001124994,0.00008511677,0.02343022,0.0001880976],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915249,0.001216854,0.000006467215,0.0005875053,0.000165227,0.003153579,0.00004271317,0.00004362328,0.00325916],"genre_scores_gemma":[0.9940869,0.0001730336,0.0007549077,0.0006857406,0.000326517,0.001115747,0.00007844785,0.00006184384,0.002716888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07993102,"threshold_uncertainty_score":0.7187973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04777988147615729,"score_gpt":0.3596446980371761,"score_spread":0.3118648165610188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}