{"id":"W4306940023","doi":"10.1182/blood.2022016362","title":"Venetoclax and idasanutlin in relapsed/refractory AML: a nonrandomized, open-label phase 1b trial","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"Foundation Medicine; Genentech","keywords":"Venetoclax; Medicine; Internal medicine; Gastroenterology; Neutropenia; Febrile neutropenia; Oncology; Leukemia; Chemotherapy; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009178118,0.0007817693,0.001082763,0.0002591261,0.0001951351,0.000653523,0.0005549145,0.0008332887,0.003464981],"category_scores_gemma":[0.0006781336,0.0002502705,0.0005169499,0.0003006978,0.0005101789,0.0004287684,0.000233912,0.00200163,0.000528525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005432773,"about_ca_system_score_gemma":0.0007530721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005091291,"about_ca_topic_score_gemma":0.001679408,"domain_scores_codex":[0.999765,0.0001374264,0.000007722235,0.00003990557,0.0000202104,0.00002971921],"domain_scores_gemma":[0.999697,0.00007267513,0.00007001821,0.00002494344,0.00001472156,0.0001205584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7610807,0.02887717,0.003643024,0.001390263,0.0008413414,0.0002310985,0.0002075784,0.002311183,0.03906426,0.0008652929,0.005126629,0.1563614],"study_design_scores_gemma":[0.7609653,0.2201828,0.008034777,0.00007526507,0.0002609254,0.0003110539,0.000045226,0.00158548,0.002637551,0.000328566,0.00554842,0.0000246825],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903381,0.004626306,0.000331302,0.0003856317,0.0001354869,0.001320255,0.0007134542,0.000107045,0.002042219],"genre_scores_gemma":[0.9884382,0.003209907,0.001488924,0.000749959,0.0001922927,0.001455442,0.001536932,0.00002589754,0.002902407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003464981,"threshold_uncertainty_score":0.01159149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04777988147615729,"score_gpt":0.3596446980371761,"score_spread":0.3118648165610188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}