{"id":"W4306955734","doi":"10.1016/j.eururo.2022.10.004","title":"Upfront Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma Treated with Immune Checkpoint Inhibitors or Targeted Therapy: An Observational Study from the International Metastatic Renal Cell Carcinoma Database Consortium","year":2022,"lang":"en","type":"article","venue":"European Urology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre; Dalhousie University; University of Calgary; William Osler Health System","funders":"Office of Research, Innovation and Commercialization, University of Agriculture Faisalabad; Genentech; Astellas Pharma; Calithera Biosciences; Bayer Fund; Ipsen Biopharmaceuticals; Exelixis; Gilead Sciences; Eisai; Merck; Bristol-Myers Squibb; AstraZeneca; Novartis; Pfizer","keywords":"Medicine; Renal cell carcinoma; Nephrectomy; Oncology; Internal medicine; Nivolumab; Observational study; Urology; Immunotherapy; Kidney; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001238761,0.0006714709,0.00082593,0.0002650743,0.0005316687,0.00006933277,0.0007278057,0.00003266409,0.001601496],"category_scores_gemma":[0.000119221,0.0004287008,0.0002717888,0.0004292559,0.0002799538,0.0002184878,0.0003766104,0.0006821338,0.00003756747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004292417,"about_ca_system_score_gemma":0.0006698561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001430886,"about_ca_topic_score_gemma":0.000118509,"domain_scores_codex":[0.9937632,0.002359577,0.001099039,0.001237379,0.0008981428,0.0006426256],"domain_scores_gemma":[0.9967865,0.0007490629,0.0006976743,0.001104299,0.0003806087,0.0002818914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0893683,0.01683089,0.3511267,0.00007976545,0.004431531,0.01342221,0.01756343,0.002652213,0.494667,0.00005380254,0.008592193,0.001211932],"study_design_scores_gemma":[0.03675995,0.03302781,0.8180726,0.00001172896,0.00282531,0.000663074,0.008504356,0.002140309,0.0853153,0.00003068525,0.01179994,0.0008489079],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913342,0.001120241,0.0002611532,0.001069277,0.0003976977,0.003688473,0.001429961,0.0001009537,0.0005980622],"genre_scores_gemma":[0.9864498,0.000007370785,0.003649261,0.001071211,0.0004194826,0.0007751253,0.006335569,0.0001887974,0.001103397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4669459,"threshold_uncertainty_score":0.9998165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08657612802764626,"score_gpt":0.2861605605452182,"score_spread":0.199584432517572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}