{"id":"W4306955734","doi":"10.1016/j.eururo.2022.10.004","title":"Upfront Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma Treated with Immune Checkpoint Inhibitors or Targeted Therapy: An Observational Study from the International Metastatic Renal Cell Carcinoma Database Consortium","year":2022,"lang":"en","type":"article","venue":"European Urology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre; Dalhousie University; University of Calgary; William Osler Health System","funders":"Office of Research, Innovation and Commercialization, University of Agriculture Faisalabad; Genentech; Astellas Pharma; Calithera Biosciences; Bayer Fund; Ipsen Biopharmaceuticals; Exelixis; Gilead Sciences; Eisai; Merck; Bristol-Myers Squibb; AstraZeneca; Novartis; Pfizer","keywords":"Medicine; Renal cell carcinoma; Nephrectomy; Oncology; Internal medicine; Nivolumab; Observational study; Urology; Immunotherapy; Kidney; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003169685,0.0004099395,0.001138117,0.0009249195,0.0007837786,0.001186743,0.001232592,0.0005538194,0.001115336],"category_scores_gemma":[0.007310076,0.0005085849,0.001184941,0.003379186,0.0004296135,0.00070007,0.001246537,0.001129667,0.0001677892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001183297,"about_ca_system_score_gemma":0.001778417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01682042,"about_ca_topic_score_gemma":0.02146198,"domain_scores_codex":[0.9954783,0.001500636,0.0006252753,0.001031308,0.001028437,0.0003360838],"domain_scores_gemma":[0.9898494,0.001783015,0.005730486,0.001052602,0.0007170895,0.0008673517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000303768,0.00007647115,0.9981047,0.00004816686,0.0002776092,0.00006380447,0.00007932851,0.00004030765,0.0000775299,0.0000316756,0.0002916117,0.000604975],"study_design_scores_gemma":[0.0001443987,0.0001564001,0.9972183,0.00005957353,0.0003435705,0.0004830673,0.0003360341,0.0003736721,0.00008359305,0.00004191769,0.0007466763,0.00001275879],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954158,0.00100394,0.0002709342,0.0001074292,0.00001517397,0.00007383268,0.002741487,0.000003884989,0.0003674462],"genre_scores_gemma":[0.9950575,0.0003619964,0.0002319202,0.0001418944,0.00002843084,0.00008126696,0.004022133,0.000004458725,0.00007039317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01682042,"threshold_uncertainty_score":0.03344506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08657612802764626,"score_gpt":0.2861605605452182,"score_spread":0.199584432517572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}