{"id":"W4306958170","doi":"10.1016/j.bioorg.2022.106175","title":"Synthesis, characterization, in-silico, and pharmacological evaluation of new 2-amino-6‑trifluoromethoxy benzothiazole derivatives","year":2022,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Winnipeg","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Benzothiazole; Chemistry; Glutathione; Neuroinflammation; Oxidative stress; Lipid peroxidation; In vivo; Pharmacology; Docking (animal); Biochemistry; Antioxidant; Stereochemistry; Enzyme; Inflammation; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002397264,0.0003044333,0.0002348562,0.000216399,0.000187249,0.0001670051,0.000330997,0.0003409779,0.001172363],"category_scores_gemma":[0.0001914189,0.0001329742,0.0002690987,0.0001634038,0.0001209736,0.0001282269,0.0001026284,0.0003288149,0.0004316052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002683741,"about_ca_system_score_gemma":0.0002953049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001422299,"about_ca_topic_score_gemma":0.003675702,"domain_scores_codex":[0.9998678,0.0000255514,0.000008587584,0.0000180495,0.00004231348,0.00003769962],"domain_scores_gemma":[0.9999111,0.00001199389,0.00003139543,0.000007694163,0.00002277773,0.000015147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008395215,0.00004411076,0.00008799461,0.00005840178,0.000007343041,0.00006953841,0.0000142454,0.0002446804,0.9964282,0.00006930668,0.00008747268,0.002804788],"study_design_scores_gemma":[0.00006365796,0.00192853,0.002713651,0.00001303739,0.00006084785,0.0004436835,0.00002037831,0.001547041,0.9853543,0.00002645997,0.00781354,0.00001480204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701409,0.007817289,0.01584074,0.0003086808,0.00006357674,0.0002576843,0.0009078942,0.0001821805,0.004480954],"genre_scores_gemma":[0.9749888,0.004580041,0.0126342,0.0001191609,0.00002763616,0.0001201612,0.001289448,0.00002093365,0.006219576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422299,"threshold_uncertainty_score":0.003921926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05072982460528083,"score_gpt":0.2816375929670493,"score_spread":0.2309077683617685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}