{"id":"W4307023798","doi":"10.1016/j.cjca.2022.08.024","title":"EXTRACELLULAR VESICLES FROM HUMAN HEART EXPLANT-DERIVED CELLS ATTENUATE ACTIVATION OF THE NLRP3 INFLAMMASOME IN MACROPHAGES","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Inflammasome; Inflammation; Medicine; Cell biology; Microvesicles; Microvesicle; Basigin; Innate immune system; Immune system; Molecular biology; Immunology; Biology; Biochemistry; microRNA; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004550352,0.0003711232,0.000673001,0.000231817,0.0002045684,0.0008258377,0.000246464,0.000697318,0.001772914],"category_scores_gemma":[0.0005061313,0.0001855169,0.0005690408,0.0001489076,0.0003094214,0.0005535553,0.0005789546,0.001259419,0.0005470156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002246677,"about_ca_system_score_gemma":0.0004021853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005291084,"about_ca_topic_score_gemma":0.0005174562,"domain_scores_codex":[0.999656,0.00009579843,0.00003770843,0.00004575344,0.00006508818,0.00009980782],"domain_scores_gemma":[0.9998036,0.00006487982,0.00003646665,0.00003601466,0.00002935052,0.00002967444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002303328,0.000178403,0.0002994252,0.000193574,0.00005414389,0.0002129547,0.0001236528,0.0002265361,0.9922374,0.0003571882,0.0002910362,0.003522345],"study_design_scores_gemma":[0.0003362881,0.001798032,0.004874935,0.00006631087,0.0001022113,0.0005314103,0.0002624643,0.001521349,0.9849322,0.0002633134,0.00529407,0.00001736404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892699,0.00461848,0.003225603,0.0004806826,0.000309539,0.00006781582,0.0005702428,0.00005801425,0.001399698],"genre_scores_gemma":[0.9941487,0.001441675,0.001280586,0.0001105021,0.00005706629,0.00005305494,0.000791731,0.00002670733,0.002089992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001772914,"threshold_uncertainty_score":0.00593096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013273469461753,"score_gpt":0.2143407974747835,"score_spread":0.204208062780166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}