{"id":"W4307023812","doi":"10.1016/j.cjca.2022.08.036","title":"SIRT3 PREVENTS DOXORUBICIN INDUCED DILATED CARDIOMYOPATHY VIA REGULATION OF MITOCHONDRIAL PROTEIN ACETYLATION: INVESTIGATING METABOLIC DYSFUNCTION AS A RESULT OF ALTERATIONS TO CARDIAC LIPIDS","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Manitoba","funders":"","keywords":"SIRT3; Sirtuin; Medicine; Dilated cardiomyopathy; Cardiomyopathy; Mitochondrion; Acetylation; Endocrinology; Internal medicine; Pharmacology; Heart failure; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002052314,0.0004084218,0.0006310405,0.000232444,0.0002378631,0.0002627246,0.0003586627,0.0005202077,0.002649438],"category_scores_gemma":[0.0001457794,0.0002148207,0.0004711966,0.0001611596,0.0004682776,0.000437825,0.0002210972,0.001166065,0.0002917164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002880602,"about_ca_system_score_gemma":0.0003853101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097182,"about_ca_topic_score_gemma":0.002865266,"domain_scores_codex":[0.9999045,0.00001743797,0.000007733086,0.00002081513,0.00001385425,0.00003566163],"domain_scores_gemma":[0.9999053,0.000008160151,0.00002622526,0.00001531636,0.0000112528,0.00003371581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009949765,0.0008409265,0.0008909042,0.0002171849,0.00008766889,0.000126126,0.00006968415,0.0001407089,0.9776844,0.0003672757,0.0003652578,0.009260061],"study_design_scores_gemma":[0.001861773,0.01433225,0.03353062,0.00006589435,0.0005858147,0.0004398035,0.0003388373,0.002474585,0.9371973,0.0004917577,0.008628215,0.00005319682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919612,0.003552862,0.001998129,0.0004898779,0.0002143574,0.00005520978,0.000306808,0.0001707128,0.001250848],"genre_scores_gemma":[0.9957099,0.001138961,0.0008018095,0.0001449177,0.0000279552,0.00003429372,0.0002096184,0.00001889675,0.001913683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002649438,"threshold_uncertainty_score":0.008863211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01760215953298808,"score_gpt":0.254728326430379,"score_spread":0.2371261668973909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}